Tryptophan, Serotonin, and Melatonin pp 341-346 | Cite as
Effect of Albumin Administration on L-Tryptophan Levels in the Serum and Tissues of Rats with Puromycin Aminonucleoside-Induced Nephrosis
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Abstract
We examined the effect of albumin administration on L-tryptophan (Trp) levels in the serum and tissues of rats with puromycin aminonucleoside (PAN)-induced nephrosis. PNA-injected rats showed increased urinary protein and serum non-esterified fatty acids levels and decreased serum albumin level at 8 days after the injection. The nephrotic rats showed a decrease in total serum Trp level and increases in free serum Trp and liver and kidney Trp levels but no change in urinary Trp level. At 5 min after intravenous injection of bovine serum albumin, the nephrotic rats had serum albumin concentration similar to the level of non-nephrotic rats and showed a recovery of decreased total serum Trp with the reduction of increased free serum Trp and liver Trp.
Keywords
Serum Albumin Level Serum Albumin Concentration Albumin Administration Puromycin Aminonucleoside Decrease Serum Albumin LevelPreview
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