Abstract
Dieting is a common behaviour which may trigger eating disorders such as bulimia nervosa in predisposed subjects. We found that in healthy women moderate dieting for 3 weeks lowered plasma concentrations of the 5-HT precursor, L-tryptophan (TRP) and impaired brain 5-HT neurotransmission as judged by 5-HT neuroendocrine tests. In recovered female subjects with a history of bulimia nervosa we found that TRP depletion produced by an amino acid mixture lacking TRP caused a temporary return of depressive symptoms together with concerns about weight and shape and fear of loss of control of eating. Taken together the data suggest that dieting-induced decreases in TRP availability may trigger the development of bulimia nervosa is susceptible individuals.
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Cowen, P.J., Clifford, E.M., Walsh, A.E.S., Williams, C., and Fairburn, C.G., 1996, Moderate dieting causes 5-HT2C receptor supersensitivity. Psychol Med 26:1155–1159.
Hsu, L.K., 1997, Can dieting cause an eating disorder? Psychol Med 27:509–513.
Jimerson, D.C., Wolfe, B.E., Metzger, E.D., Finkelstein, D.M., Cooper, T.B., and Levine, J.M., 1997, Decreased serotonin function in bulimia nervosa. Arch Gen Psychiatry 54:529–534.
Levitan, R.D., Kaplan, A.S., Joffe, R.T., Levitt, A.J., and Brown, G.M., 1997, Hormonal and subjective responses to intravenous meta-chlorophenylpiperazine in bulimia nervosa. Arch Gen Psychiatry 54:521–527.
Smith, K.A., Fairburn, C.G., and Cowen, P.J., 1997, Relapse of depression after rapid depletion of tryptophan. Lancet 349:915–919.
Tecott, L.H., Sun, L.M., Akanas, F., Strack, A.M., Lowenstein, D.H., Dallman, M.F, and Julius, D., 1995, Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors. Nature 374:542–546.
Walsh, A.E.S., Oldman, A.D., Franklin, M., Fairburn, C.G., and Cowen, P.J., 1995, Dieting decreases plasma tryptophan and increases the prolactin response to d-fenfluramine in women but not men. J Affect Disord 33:89–97.
Young, S.N., Smith, S.E., Phil, R.O., and Ervin, F.R., 1985, Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 87:173–177.
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© 1999 Springer Science+Business Media New York
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Cowen, P.J., Smith, K.A. (1999). Serotonin, Dieting, and Bulimia Nervosa. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_14
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DOI: https://doi.org/10.1007/978-1-4615-4709-9_14
Publisher Name: Springer, Boston, MA
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