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Connexin32 in Hereditary Neuropathies

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 468)

Abstract

In many developing and adult tissues, cells communicate with their immediate neighbours to achieve a coordinate response of groups of cells upon external stimuli and a rapid adaptation to the surrounding medium. Such an exchange of information can be mediated through cytosolic molecules such as ions, second messengers, and small metabolites via intercellular channels called gap junctions which connect adjacent cells. In electron microscopical analysis, the gap junction is characterised by a close apposition of the outer leaflets of the plasma membranes of two neighbouring cells which remain separated by an approximately 2 to 4nm wide space or gap.

Keywords

Schwann Cell Hereditary Neuropathy Myelin Protein Zero PMP22 Gene Cx32 Gene 
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© Springer Science+Business Media New York 1999

Authors and Affiliations

  1. 1.Institute of Cell Biology Department of BiologySwiss Federal Institute of TechnologyZürichSwitzerland
  2. 2.Institute of Cell BiologyZürichSwitzerland

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