Oxidants and Antioxidants in Platelet Function

  • Jane E. Freedman
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 224)


Epidemiological studies have shown that dietary antioxidant consumption is inversely associated with the development of coronary artery disease. The precise mechanisms that underlie these observations, however, are not clear. While the beneficial effects of antioxidants have been attributed to the prevention of oxidative modification of low-density lipoprotein (LDL) and the inhibition of atherogenesis, other factors may also be important. Platelet fonction is dependent upon the balance between oxidative stress and antioxidant protection and, importantly, platelets have been implicated in the development of atherosclerosis, as well as in the acute occlusion of coronary vessels (1,2).


Nitric Oxide Platelet Aggregation Glutathione Peroxidase Platelet Function Human Platelet 
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© Springer Science+Business Media New York 2000

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  • Jane E. Freedman

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