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Oxidative Stress and Vascular Disease pp 183–194Cite as

Oxidants and Antioxidants in Platelet Function

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 224))

Abstract

Epidemiological studies have shown that dietary antioxidant consumption is inversely associated with the development of coronary artery disease. The precise mechanisms that underlie these observations, however, are not clear. While the beneficial effects of antioxidants have been attributed to the prevention of oxidative modification of low-density lipoprotein (LDL) and the inhibition of atherogenesis, other factors may also be important. Platelet fonction is dependent upon the balance between oxidative stress and antioxidant protection and, importantly, platelets have been implicated in the development of atherosclerosis, as well as in the acute occlusion of coronary vessels (1,2).

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Authors
  1. Jane E. Freedman
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Editors and Affiliations

  1. Boston University School of Medicine, Boston, MA, USA

    John F. Keaney Jr. M.D. (Associate Professor of Medicine and Pharmacology) (Associate Professor of Medicine and Pharmacology)

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Freedman, J.E. (2000). Oxidants and Antioxidants in Platelet Function. In: Keaney, J.F. (eds) Oxidative Stress and Vascular Disease. Developments in Cardiovascular Medicine, vol 224. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4649-8_10

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  • DOI: https://doi.org/10.1007/978-1-4615-4649-8_10

  • Publisher Name: Springer, Boston, MA

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