Microalbuminuria and Cardiovascular Disease

  • S. M. Thomas
  • G. C. Viberti


The term microalbuminuria was first coined in 1969 by Keen and Chlouverakis in Guy’s Hospital Reports 1969 [1] when following the development of a radioimmunoassay to detect low concentrations of albumin in the urine [2], urinary albumin excretion rate (AER) was determined in a population of patients with type 2 diabetes. Parving et al in 1974 described that this phenomenon was associated with essential hypertension and in the early 1980’s the predictive value of microalbuminuria for overt nephropathy and renal failure in diabetes was described. Since that time there has been an explosion of interest in microalbuminuria and it’s associations. Microalbuminuria is now defined as an AER of 20–200μg/min or 30 – 300 mg/day.


Essential Hypertension Urinary Albumin Excretion Rate Overt Nephropathy Conventional Cardiovascular Risk Factor Hypertensive Parent 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • S. M. Thomas
    • 1
  • G. C. Viberti
    • 1
  1. 1.Department of EndocrinologyDiabetes & Internal Medicine Division of Medicine GKT School of Medicine Guy’s Hospital Campus KCLLondonUK

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