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Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors

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The Kidney and Hypertension in Diabetes Mellitus

Abstract

Glomerular hyperfiltration in insulin-dependent (Type 1) diabetes mellitus of short duration has been recognized for many years [1–3], with increments in renal plasma flow (RPF) and nephromegaly [3]. With the finding of early hyperfiltration, Stalder and Schmid proposed that these early functional changes may predispose to the subsequent development of diabetic glomerulopathy [1]. Further support for the hypothesis that renal hyperperfusion and hyperfiltration contribute to diabetic glomerulopathy came from the finding of diabetic glomerulopathy only in the non-stenosed kidney in the setting of unilateral renal artery stenosis [4].

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland, OR, USA

    Sharon Anderson M.D. & Radko Komers M.D., Ph.D.

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  1. Sharon Anderson M.D.
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  2. Radko Komers M.D., Ph.D.
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Editors and Affiliations

  1. Medical Department M (Diabetes & Endocrinology), Aarhus Kommunehospital Aarhus University Hospital, Aarhus C, Denmark

    Carl Erik Mogensen

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© 2000 Springer Science+Business Media New York

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Anderson, S., Komers, R. (2000). Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors. In: Mogensen, C.E. (eds) The Kidney and Hypertension in Diabetes Mellitus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4499-9_24

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  • DOI: https://doi.org/10.1007/978-1-4615-4499-9_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7028-4

  • Online ISBN: 978-1-4615-4499-9

  • eBook Packages: Springer Book Archive

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