Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression

  • Levon M. Khachigian
  • Yoh Takuwa
  • Tucker Collins
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 33)


Angiotensin II induces the expression of platelet-derived growth factorA-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall. This review is concerned with recent developments in our understanding of the signaling and transcriptional mechanisms mediating the inducible expression of one vasoconstrictor by another. (Mol Cell Biochem 212: 183–186, 2000)

Key words

angiotensin platelet-derived growth factor transcriptional regulation Egr-1 


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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Levon M. Khachigian
    • 1
    • 2
    • 5
  • Yoh Takuwa
    • 3
  • Tucker Collins
    • 4
  1. 1.Centre for Thrombosis and Vascular ResearchThe University of New South WalesSydneyAustralia
  2. 2.Department of HaematologyPrince of Wales HospitalSydneyAustralia
  3. 3.Department of PhysiologyKanazawa University School of MedicineKanazawaJapan
  4. 4.Vascular Research Division, Department of PathologyBrigham and Women’s Hospital & Harvard Medical SchoolBostonUSA
  5. 5.Centre for Thrombosis and Vascular Research, School of PathologyThe University of New South WalesSydneyAustralia

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