Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB

  • Philipp Haus-Seuffert
  • Michael Meisterernst
Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 33)

Abstract

The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context-and position-specific function of CREB on complex genes. (Mol Cell Biochem 212: 5–9, 2000)

Key words

transcriptional regulation gene expression coactivator repressor 

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Philipp Haus-Seuffert
    • 1
  • Michael Meisterernst
    • 1
    • 2
  1. 1.Institute of Molecular Immunology, Department for ProteinbiochemistryGSFMünchenGermany
  2. 2.Institute of Molecular Immunology, Department for ProteinbiochemistryGSFMünchenGermany

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