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Progress in Cell Cycle Research pp 157–162Cite as

HTLV-I Tax and cell cycle progression

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Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Human T-cell leukemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukemia (ATL) and various human myopathies/neuropathies. HTLV-I encodes a 40 kDa phosphoprotein, Tax, which has been implicated in cellular transformation. In similarity with several other oncoproteins such as Myc, Jun, and Fos, Tax is a transcriptional activator. How Tax mechanistically dysregulates the cell cycle remains unclear. Recent findings from us and others have shown that Tax targets key regulators of G1/S and M progression such as p16INK4a, cyclin D1, cyclin D3-cdk, and the mitotic spindle checkpoint apparatus. Thus, Tax influences the progression of cells in various phases of the cell cycle. In this regard, we will discuss three distinct mechanisms through which Tax affects cell-cycling a) through direct association Tax can abrogate the inhibitory function of p16INK4a on the G1-cdks, b) Tax can also directly influence cyclin D-cdk activities by a protein-protein interaction, and c) Tax targets the HsMAD1 mitotic spindle-assembly checkpoint protein. Through these varied routes, the HTLV-I oncoprotein dysregulates cellular growth controls and engenders a proclivity of cells toward a loss of DNA-damage surveillance.

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References

  1. Hollsberg, P. and Hafler, D. A. (1993) N. Engl. J. Med. 328, 1173–1182.

    Article  PubMed  CAS  Google Scholar 

  2. Jeang, K T., Shank, P. R. and Kumar, A. (1988) Proc. Natl. Acad. Sci. U S A 85, 8291–8295.

    Article  PubMed  CAS  Google Scholar 

  3. Seiki, M., Inoue, J., Takeda, T. and Yoshida, M. (1986) Embo J. 5, 561–5.

    PubMed  CAS  Google Scholar 

  4. Yoshida, M. (1993) Trends Microbiol. 1, 131–135.

    CAS  Google Scholar 

  5. Nerenberg, M., Hinrichs, S. H., Reynolds, R. K, Khoury, G. and Jay, G. (1987) Science 237, 1324–9.

    Article  PubMed  CAS  Google Scholar 

  6. Grassmann, R., Berchtold, S., Radant, I., Alt, M., Fleckenstein, B., Sodroski, J. G., Haseltine, W. A. and Ramstedt, U. (1992) J. Viral. 66, 4570–5.

    CAS  Google Scholar 

  7. Grossman, W. J., Kimata, J. T., Wong, F. H., Zutter, M., Ley, T. J. and Ratner, L. (1995) Proc. Natl. Acad. Sci. U S A 92, 1057–61.

    Article  PubMed  CAS  Google Scholar 

  8. Inoue, J., Seiki, M., Taniguchi, T., Tsuru, S. and Yoshida, M. (1986) Embo J. 5, 2883–8.

    PubMed  CAS  Google Scholar 

  9. Siekevitz, M., Josephs, S. F., Dukovich, M., Peffer, N., Wong-Staal, F. and Greene, W. C. (1987) Science 238, 1575–8.

    Article  PubMed  CAS  Google Scholar 

  10. Ballard, D. W., Bohnlein, E., Lowenthal, J. W., Wano, Y., Franza, B. R. and Greene, W. C. (1988) Science 241,1652–5.

    Article  PubMed  CAS  Google Scholar 

  11. Fujii, M., Sassone-Corsi, P. and Verma, I. M. (1988) Proc. Natl. Acad. Sci. USA 85, 8526–30.

    Article  PubMed  CAS  Google Scholar 

  12. Fujii, M., Niki, T., Mori, T., Matsuda, T., Matsui, M., Nomura, N. and Seiki, M. (1991) Oncogene 6, 1023–9.

    PubMed  CAS  Google Scholar 

  13. Miyatake, S., Seild, M., Yoshida, M. and Arai, K. (1988) Mol. Cell. Biol. 8, 5581–7.

    PubMed  CAS  Google Scholar 

  14. Ruben, S., Poteat, H., Tan, T. H., Kawakami, K, Roeder, R., Haseltine, W. and Rosen, C. A. (1988) Science 241, 89–92.

    Article  PubMed  CAS  Google Scholar 

  15. Alexandre, C., Charnay, P. and Verrier, B. (1991) Oncogene 6, 1851–7.

    PubMed  CAS  Google Scholar 

  16. Jeang, K. T., Widen, S. G., Semmes, O. t and Wilson, S. H. (1990) Science 247, 1082–4

    Article  PubMed  CAS  Google Scholar 

  17. Uittenbogaard, M. N., Giebler, H. A., Reisman, D. and Nyborg, J. K. (1995) J. Biol. Chem. 270, 28503–6.

    Article  PubMed  CAS  Google Scholar 

  18. Semmes, O. J., Barret, J. F., Dang C. V. and Jeang, K T. (1996) J. Biol. Chem. 271, 9730–8.

    Article  PubMed  CAS  Google Scholar 

  19. Brauweiler, A., Garrus, J. E., Reed, J. C. and Nyborg, J. K. (1997) Virology 231, 135–40.

    Article  PubMed  CAS  Google Scholar 

  20. Pozzatti, R., Vogel, J. and Jay, G. (1990) Mol. Cell. Biol. 10, 413–7.

    PubMed  CAS  Google Scholar 

  21. Trihn, D., Jeang, K. T. and Semmes, O. J. (1997) Journal of Biomedical Science 4, 47–53.

    Article  PubMed  CAS  Google Scholar 

  22. Franklin, A. A. and Nyborg, J. K. (1995) J. Biomed. Sci. 2, 17–29.

    Article  PubMed  CAS  Google Scholar 

  23. Hunter, T. and Pines, J. (1994) Cell. 79, 573–82.

    Article  PubMed  CAS  Google Scholar 

  24. Peters, G. (1994) J. Cell Sci. Suppi. 18, 89–96.

    CAS  Google Scholar 

  25. Hirama, T. and Koeffler, H. P. (1995) Blood 86, 841–54.

    PubMed  CAS  Google Scholar 

  26. Jansen-Durr, P. (1996) Trends Genet. 12, 270–5.

    Article  PubMed  CAS  Google Scholar 

  27. Murray, A. (1994) Curr. Opin. Cell Biol. 6, 872–6.

    Article  PubMed  CAS  Google Scholar 

  28. Peter, M. and Herskowitz, I. (1994) Cell 79, 181–4.

    Article  PubMed  CAS  Google Scholar 

  29. Sherr, C. J. (1994) Cell 79, 551–5.

    Article  PubMed  CAS  Google Scholar 

  30. Grana, X. and Reddy, E. P. (1995) Oncogene 11, 211–9.

    PubMed  CAS  Google Scholar 

  31. Morgan, D. O. (1995) Nature 374, 131–4.

    Article  PubMed  CAS  Google Scholar 

  32. Sherr, C. J. and Roberts, J. M. (1995) Genes Dev. 9, 1149–63.

    Article  PubMed  CAS  Google Scholar 

  33. Sherr, C. J. (1995) Trends Biochem. Sci.20, 187–90.

    Article  PubMed  CAS  Google Scholar 

  34. Matsushime, H., Quelle, D. E., Shurtleff, S. A., Shibuya, M., Sherr, C. J. and Kato, J. Y. (1994) Mol. Cell. Biol. 14, 2066–76.

    PubMed  CAS  Google Scholar 

  35. Resnitzky, D., Gossen, M., Bujard, H. and Reed, S. I. (1994) Mol. Cell. Biol. 14, 1669–79.

    PubMed  CAS  Google Scholar 

  36. Nevins, J. R. (1992) Science 258, 424–9.

    Article  PubMed  CAS  Google Scholar 

  37. Dowdy, S. F., Hinds, P. W., Louie, K., Reed, S. I., Arnold, A. and Weinberg, R. A. (1993) Cell 73, 499–511.

    Article  PubMed  CAS  Google Scholar 

  38. Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J. and Livingston, D. M. (1993) Cell 73, 487–97.

    Article  PubMed  CAS  Google Scholar 

  39. DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J. Y., Huang, C. M., Lee, W. H., Marsilio, E., Paucha, E. and Livingston, D. M. (1988) Cell 54, 275–83.

    Article  PubMed  CAS  Google Scholar 

  40. Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A. and Harlow, E. (1988) Nature 334, 124–9.

    Article  PubMed  CAS  Google Scholar 

  41. Dyson, N., Howley, P. M., Munger, K. and Harlow, E. (1989) Science 243, 934–7.

    Article  PubMed  CAS  Google Scholar 

  42. Boyer, S. N., Wazer, D. E. and Band, V. (1996) Cancer Res. 56, 4620–4.

    PubMed  CAS  Google Scholar 

  43. Jones, D. L. and Munger, K. (1997) J. Virol. 71, 2905–12.

    PubMed  CAS  Google Scholar 

  44. Johnson, D. G., Schwarz, J. K, Cress, W. D. and Nevins, J. R. (1993) Nature 365, 349–52.

    Article  PubMed  CAS  Google Scholar 

  45. Qin, X. Q., Livingston, D. M., Kaelin, W., Jr. and Adams, P. D. (1994) Proc. Natl. Acad. Sci. U S A 91, 10918–22.

    Article  PubMed  CAS  Google Scholar 

  46. Majone, F., Semmes, O. J. and Jeang, K. T. (1993) Virology 193, 456–9.

    Article  PubMed  CAS  Google Scholar 

  47. Semmes, O. J., Majone, F., Cantemir, C., Turchetto, L., Hjelle, B. and Jeang, K. T. (1996) Virology 217, 373–9.

    Article  PubMed  CAS  Google Scholar 

  48. Jin, D. Y., Spencer, F. and Jeang, K. T. (1998) Cell 93, 81–91.

    Article  PubMed  CAS  Google Scholar 

  49. Low, K. G., Dorner, L. F., Fernando, D. B., Grossman, J., Jeang, K. T. and Comb, M. J. (1997) J. Viral. 71, 1956–62.

    CAS  Google Scholar 

  50. Suzuki, T., Kitao, S., Matsushime, H. and Yoshida, M. (1996) Embo J. 15,1607–14.

    PubMed  CAS  Google Scholar 

  51. Hinds, P. W. and Weinberg, R. A. (1994) Curr Opin. Genet. Dev. 4, 135–41.

    Article  PubMed  CAS  Google Scholar 

  52. Kato, J. Y. and Sherr, C. J. (1993) Proc. Natl. Acad. Sci. U S A 90,11513–7.

    Article  PubMed  CAS  Google Scholar 

  53. Rao, S. S., Chu, C. and Kohtz, D. S. (1994) Mol. Cell. Biol. 14, 5259–67.

    PubMed  CAS  Google Scholar 

  54. Skapek, S. X., Rhee, J., Spicer, D. B. and Lassar, A B. (1995) Science 267, 1022–4.

    Article  PubMed  CAS  Google Scholar 

  55. Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mandavi, V. and Nadal-Ginard, B. (1993) Cell 72, 309–24.

    Article  PubMed  CAS  Google Scholar 

  56. Schneider, J. W., Gu, W., Zhu, L., Mandavi, V. and Nadal-Ginard, B. (1994) Science 264, 1467–71.

    Article  PubMed  CAS  Google Scholar 

  57. Martelli, F., Cenciarelli, C., Santarelli, G., Polikar, B., Felsani, A. and Caruso, M. (1994) Oncogene 9, 3579–90.

    PubMed  CAS  Google Scholar 

  58. Wang, J. and Nadal-Ginard, B. (1995) Biochem. Biophys. Res. Commun. 206, 82–8.

    Article  PubMed  CAS  Google Scholar 

  59. Neuveut, C., Low, K. G., Maldarelli, F., Schmitt, I., Majone, F., Grassmann, R. and Jeang, K. T. (1998) Mol. Cell. Biol. 18, 3620–32.

    PubMed  CAS  Google Scholar 

  60. Matsushime, H., Roussel, M. F., Ashmun, R. A. and Sherr, C. J. (1991) Cell 65, 701–13.

    Article  PubMed  CAS  Google Scholar 

  61. Steiner, P., Philipp, A., Lukas, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bartel, J. and Eilers, M. (1995) Embo J. 14, 4814–26.

    PubMed  CAS  Google Scholar 

  62. Diehl, J. A., Zindy, F. and Sherr, C. J. (1997) Genes Dev. 11, 957–72.

    Article  PubMed  CAS  Google Scholar 

  63. Hannon, G. J. and Beach, D. (1994) Nature 371, 257–61.

    Article  PubMed  CAS  Google Scholar 

  64. Guan, K. L, Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O’Keefe, C. L, Matera, A. G. and Xiong, Y. (1994) Genes Dev. 8, 2939–52.

    Article  PubMed  CAS  Google Scholar 

  65. Hirai, H., Roussel, M. F., Kato, J. Y., Ashmun, R. A. and Sherr, C. J. (1995) Mol. Cell. Biol. 15, 267–281.

    Google Scholar 

  66. Chan, F. K., Zhang, J., Cheng, L., Shapiro, D. N. and Winoto, A. (1995) Mol. Cell. Bio1. 15, 2682–8.

    CAS  Google Scholar 

  67. Faha, B., Harlow, E. and Lees, E. (1993) J. Virol. 67, 2456–65.

    PubMed  CAS  Google Scholar 

  68. Arroyo, M., Bagchi, S. and Raychaudhuri, P. (1993) Mol. Cell. Biol. 13, 6537–46.

    PubMed  CAS  Google Scholar 

  69. McIntyre, M. C., Ruesch, M. N. and Laimins, L. A. (1996) Virology 215, 73–82.

    Article  PubMed  CAS  Google Scholar 

  70. Tommasino, M., Adamczewski, J. P., Carlotti, F., Barth, C. F., Manetti, R., Contorni, M., Cavalieri, F., Hunt, T. and Crawford, L. (1993) Oncogene 8, 195–202.

    PubMed  CAS  Google Scholar 

  71. Rudner, A. D. and Murray, A. W. (1996) Curr. Opin. Cell. Biol. 8, 773–80.

    Article  PubMed  CAS  Google Scholar 

  72. Arnold, A., Kim, H. G., Gaz, R. D., Eddy, R. L., Fukushima, Y., Byers, M. G., Shows, T. B. and Kronenberg, H. M. (1989) J. Clin. Invest. 83, 203–440.

    Article  Google Scholar 

  73. Motokura, T., Bloom, T., Kim, H. G., Juppner, H., Ruderman, J. V., Kronenberg, H. M. and Arnold, A. (1991) Nature 350, 512–5.

    Article  PubMed  CAS  Google Scholar 

  74. Erikson, J., Finan, J., Tsujimoto, Y., Nowell, P. C. and Croce, C. M. (1984) Proc. Natl. Acad. Sci. U S A 81, 4144–8.

    Article  PubMed  CAS  Google Scholar 

  75. Tsujimoto, Y., Yunis, J., Onorato-Showe, L., Erikson, J., Nowell, P. C. and Croce, C. M. (1984) Science 224, 1403–6.

    Article  PubMed  CAS  Google Scholar 

  76. Lammie, G. A. and Peters, G. (1991) Cancer Cells. 3, 413–20.

    PubMed  CAS  Google Scholar 

  77. Jiang, W., Kahn, S. M., Tonvita, N., Zhang, Y. J., Lu, S. H. and Weinstein, I. B. (1992) Cancer Res. 52, 2980–3.

    PubMed  CAS  Google Scholar 

  78. Buckley, M. F., Sweeney, K. J., Hamilton, J. A., Sini, R. L, Manning, D. L., Nicholson, R. I., deFazio, A., Watts, C. K., Musgrove, E. A. and Sutherland, R. L. (1993) Oncogene 8, 2127–33.

    PubMed  CAS  Google Scholar 

  79. Tarn, S. W., Theodoras, A. M., Shay, J. W., Draetta, G. F. and Pagano, M. (1994) Oncogene 9, 2663–74.

    Google Scholar 

  80. Khatib, Z. A., Matsushime, H., Valentine, M., Shapiro, D. N., Sherr, C. J. and Look, A. T. (1993) Cancer Res. 53, 553–511.

    Google Scholar 

  81. Sheaff, R. J. and Roberts, J. M. (1995) Curr. Biol. 5, 28–31.

    CAS  Google Scholar 

  82. Li, R. and Murray, A. W. (1991) Cell 66, 519–31.

    Article  PubMed  CAS  Google Scholar 

  83. Pangilinan, F. and Spencer, F. (1996) Mol. Biol. Cell 7, 1195–208.

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut Pasteur, Laboratoire de Recombinaison et Expression Genetique, 28, rue du Dr Roux, 75724, Paris cedex 15, France

    Christine Neuveut

  2. National Institute of Allergy and Infectious Diseases, Laboratory of Molecular Microbiology, Building 4 Room 302, 9000 Rockville Pike, Bethesda, MD, 20892-0460, USA

    Kuan-Teh Jeang

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  1. Christine Neuveut
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  2. Kuan-Teh Jeang
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Editors and Affiliations

  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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Neuveut, C., Jeang, KT. (2000). HTLV-I Tax and cell cycle progression. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_14

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  • DOI: https://doi.org/10.1007/978-1-4615-4253-7_14

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