Recombination and Human Diversity
Recombination has classically been viewed as generating diversity by crossing-over between chromosomes, so that new haplotypic combinations are formed. More recently it has become apparent that recombinational mechanisms, and in particular, patches of gene conversion, are active in the generation of new allelic diversity at individual loci. This review will examine work on the role of recombination in generating human diversity, in particular recent analyses of spatial heterogeneity in rates of recombination across the genome, as well as approaches to demonstrating individual or allelic heterogeneity in crossover rates.
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