Abstract
Knowing the location of human disease genes is a first step towards a characterization of the gene, and an eventual understanding of the nature of the defect and the development of therapies or even cures. This process is necessarily within the realm of molecular genetics, but there does seem to be a role for a statistician in at least the early stages of a search. This role is generally centered on an examination of the joint behavior of the disease and a series of marker loci, either within families or within populations.
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Weir, B.S. (2000). A Statistician Looks for Human Disease Genes. In: Gustafson, J.P. (eds) Genomes. Stadler Genetics Symposia Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4235-3_2
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DOI: https://doi.org/10.1007/978-1-4615-4235-3_2
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