Microvessel Density, Thymidine Phosphorylase Expression and Resistance of Head and Neck Cancer to Chemo-Radiotherapy
Cancer growth, invasion and metastasis is strongly dependent on the angiogenic ability. A growing amount of clinicopathological studies confirms that intratumoural microvessel density (MVD) is one of the strongest prognostic variables in human cancer. However, vasculature is also related to the amount of haemoglobin that reaches the tumour, thus oxygenation. Moreover, during chemotherapy, the vessel density strongly defines the drug availability to the tumour. Since euoxic conditions are related to a higher response to radiotherapy (RT) and high drug availability to higher chances for the tumour to respond to chemotherapy, it would be suggested that high microvessel density is a marker of a better response to cytotoxic therapy.
KeywordsMicrovessel Density Complete Response Rate Thymidine Phosphorylase Drug Availability Thymidine Phosphorylase Expression
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- Giatromanolaki A, Koukourakis M, Theodossiou D, et al (1997). Comparative evaluation of angiogenesis assessment with anti-Factor VIII and anti-CD31 immunostaining in non small cell lung cancer.Clin Cancer Res 3: 2493–2500Google Scholar
- Koukourakis MI. The use of Ethyol in chemotherapy and radiation therapy, in « Cytoprotection in Cancer Therapy: Improving the Therapeutic Index of Cancer Treatment.», Ethyol Investigators Meeting; ASCO May 1998, Los Angeles, California, USA.Google Scholar