Angiogenesis pp 285-289 | Cite as

Microvessel Density, Thymidine Phosphorylase Expression and Resistance of Head and Neck Cancer to Chemo-Radiotherapy

  • Michael I. Koukourakis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 476)


Cancer growth, invasion and metastasis is strongly dependent on the angiogenic ability. A growing amount of clinicopathological studies confirms that intratumoural microvessel density (MVD) is one of the strongest prognostic variables in human cancer. However, vasculature is also related to the amount of haemoglobin that reaches the tumour, thus oxygenation. Moreover, during chemotherapy, the vessel density strongly defines the drug availability to the tumour. Since euoxic conditions are related to a higher response to radiotherapy (RT) and high drug availability to higher chances for the tumour to respond to chemotherapy, it would be suggested that high microvessel density is a marker of a better response to cytotoxic therapy.


Microvessel Density Complete Response Rate Thymidine Phosphorylase Drug Availability Thymidine Phosphorylase Expression 
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  1. Fujieda S, Sunaga H, Tsuzuki H, et al (1998). Expression of platelet-derived endothelial cell growth factor in oral and oropharyngeal carcinoma. Clin Cancer Res., 4: 1583–1590PubMedGoogle Scholar
  2. Giatromanolaki A, Koukourakis M, Theodossiou D, et al (1997). Comparative evaluation of angiogenesis assessment with anti-Factor VIII and anti-CD31 immunostaining in non small cell lung cancer.Clin Cancer Res 3: 2493–2500Google Scholar
  3. Koukourakis MI, Giatromanolaki A, O’Byrne K, et al (1997). Platelet-Derived Endothelial Cell Growth Factor expression correlates with tumour angiogenesis and prognosis in non-small cell lung cancer, Br J Cancer 4: 477–481CrossRefGoogle Scholar
  4. Koukourakis MI. The use of Ethyol in chemotherapy and radiation therapy, in « Cytoprotection in Cancer Therapy: Improving the Therapeutic Index of Cancer Treatment.», Ethyol Investigators Meeting; ASCO May 1998, Los Angeles, California, USA.Google Scholar
  5. Mauceri HJ, Hanna NN, Beckett MA, et al (1998). Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature, 394: 287–291PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Michael I. Koukourakis
    • 1
  1. 1.Department of Radiotherapy and OncologyUniversity of Thessalia, Medical SchoolLarisaGreece

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