The Genetics of Hereditary Non-Polyposis Colorectal Cancer and Non-Polypotic Colon Cancer

  • Päivi Peltomäki
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 470)


Most colorectal cancers are sporadic but the lifetime risk for this cancer increases with the number of affected individuals in the pedigree. The presence of three affected relatives from two generations is compatible with autosomal dominant inheritance and fulfils the international diagnostic (”Amsterdam”) criteria for hereditary non-polyposis colorectal cancer, HNPCC.1


Colorectal Cancer Mismatch Repair Amsterdam Criterion Gene MSH2 Carcinogen Metabolism 
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Copyright information

© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Päivi Peltomäki
    • 1
  1. 1.Division of Human Cancer GeneticsComprehensive Cancer Center The Ohio State UniversityColumbusUSA

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