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Investigating the Mimetic Potential of β-Turn Mimetics

  • Susanne Winiwarter
  • Anders Hallberg
  • Anders Karlén

Abstract

The β-turn is a common structural feature in peptides and proteins, consisting of four consecutive amino acids with a distance of less than 7Å between the Cα atoms of the first and fourth amino acid (dα).1 Since β-turns are often considered to be important for molecular recognition, they are interesting templates to use in the design and synthesis of peptidomimetics. It is important to know precisely which β-turn conformation(s) the peptidomimetic corresponds to. A classification scheme that is not dependent on the peptide backbone is necessary to classify both peptides and peptidomimetics. We analysed β-turn conformations geometrically and classified them according to the relationships between the directions of the characteristic bonds 1, 2, 3 and 4 (see Figure la).

Keywords

Torsion Angle Common Structural Feature Chain Reversal Conformational Family Monte Carlo Search 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Susanne Winiwarter
    • 1
  • Anders Hallberg
    • 1
  • Anders Karlén
    • 1
  1. 1.Dept. of Organic Pharmaceutical Chemistry Uppsala Biomedical CentreUppsala UniversityUppsalaSweden

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