Investigating the Mimetic Potential of β-Turn Mimetics

  • Susanne Winiwarter
  • Anders Hallberg
  • Anders Karlén

Abstract

The β-turn is a common structural feature in peptides and proteins, consisting of four consecutive amino acids with a distance of less than 7Å between the Cα atoms of the first and fourth amino acid (dα).1 Since β-turns are often considered to be important for molecular recognition, they are interesting templates to use in the design and synthesis of peptidomimetics. It is important to know precisely which β-turn conformation(s) the peptidomimetic corresponds to. A classification scheme that is not dependent on the peptide backbone is necessary to classify both peptides and peptidomimetics. We analysed β-turn conformations geometrically and classified them according to the relationships between the directions of the characteristic bonds 1, 2, 3 and 4 (see Figure la).

Keywords

Polypeptide 

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Susanne Winiwarter
    • 1
  • Anders Hallberg
    • 1
  • Anders Karlén
    • 1
  1. 1.Dept. of Organic Pharmaceutical Chemistry Uppsala Biomedical CentreUppsala UniversityUppsalaSweden

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