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Stabilization of the Ammonium-Carboxylate Ion-Pair by an Aromatic Ring

  • Tommy Liljefors
  • Per-Ola Norrby

Abstract

A central feature in 7TM models of the binding of monoaminergic neurotransmitters to their receptors is an ammonium/carboxylate ion-pair interaction between the protonated amine and an aspartate residue in helix III.1

Keywords

Aromatic Ring Attractive Interaction Acid Complex Complexation Energy Aspartate Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Tommy Liljefors
    • 1
  • Per-Ola Norrby
    • 1
  1. 1.Department of Medicinal ChemistryRoyal Danish School of PharmacyCopenhagenDenmark

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