Stabilization of the Ammonium-Carboxylate Ion-Pair by an Aromatic Ring

  • Tommy Liljefors
  • Per-Ola Norrby


A central feature in 7TM models of the binding of monoaminergic neurotransmitters to their receptors is an ammonium/carboxylate ion-pair interaction between the protonated amine and an aspartate residue in helix III.1


Aromatic Ring Attractive Interaction Acid Complex Complexation Energy Aspartate Residue 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Tommy Liljefors
    • 1
  • Per-Ola Norrby
    • 1
  1. 1.Department of Medicinal ChemistryRoyal Danish School of PharmacyCopenhagenDenmark

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