Abstract
A central feature in 7TM models of the binding of monoaminergic neurotransmitters to their receptors is an ammonium/carboxylate ion-pair interaction between the protonated amine and an aspartate residue in helix III.1
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Trumpp-Kallmeyer S., Hoflack J., Bruinvels A., and Hibert M., J. Med. Chem. 35 (1992) 3448–62.
Heidrich H., van Eikema Hommes N. J. R. and von R. Schleyer P., J. Comput. Chem. 14 (1993) 1149–63.
Deakyne C. A. and Meot-Ner (Mautner) M. J. Am. Chem. Soc. 107 (1985) 474–9.
Dougherty, D. A., Science, 271 (1996) 163–168.
Liljefors T. and Norrby P.-O., J. Am. Chem. Soc. 119 (1997) 1052–5.
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Liljefors, T., Norrby, PO. (2000). Stabilization of the Ammonium-Carboxylate Ion-Pair by an Aromatic Ring. In: Gundertofte, K., Jørgensen, F.S. (eds) Molecular Modeling and Prediction of Bioactivity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4141-7_80
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DOI: https://doi.org/10.1007/978-1-4615-4141-7_80
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