3D QSAR of Prolyl 4-Hydroxylase Inhibitors

  • K.-H. Baringhaus
  • V. Guenzler-Pukall
  • G. Schubert
  • K. Weidmann

Abstract

Prolyl 4-hydroxylase (EC 1.14.11.2) is an important enzyme involved in collagen biosynthesis. This enzyme catalyzes the formation of 4-hydroxyproline in collagens by the hydroxylation of certain proline residues in peptide linkages1. Due to the importance of 4hydroxyproline for the thermal stability of collagenous triple helices, inhibition of this enzyme offers an attractive target for antifibrotic treatment.

Keywords

Proline Prolyl 

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • K.-H. Baringhaus
    • 1
  • V. Guenzler-Pukall
    • 1
  • G. Schubert
    • 1
  • K. Weidmann
    • 1
  1. 1.Hoechst Marion Roussel Chemical ResearchFrankfurt am MainGermany

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