Atypical Antipsychotics: Modelling and QSAR
Schizophrenia is a debilitating disease that effects approximately 1% of the population with the onset of the disease occurring usually in the mid 20’s and persisting in many cases for the lifetime of the patient. Researchers have hypothesised that schizophrenia is due to excessive limbic dopaminergic function within the brain (Jaber et al 1996).
KeywordsDopamine Schizophrenia Phenyl Serotonin Macromolecule
- Liljefors, T., Pettersson, I., 1997, “Computer aided development of three-dimensional pharmacophore models”. A Textbook of Drug Design and Development, Larson, P.K.; Liljefors, T.; Madsen, U. (editors), Publisher, Harwood Academic.Google Scholar
- Petcher, T.J., 1995, “Topology of dopamine receptors” in The Role of Brain Dopamine Fluckiger, E., Muller, E.E., Thonier, M.O., (Editors), Publisher, Springer Sandoz.Google Scholar