Advertisement

Atypical Antipsychotics: Modelling and QSAR

  • Benjamin G. Tehan
  • Margaret G. Wong
  • Graeme J. Cross
  • Edward J. Lloyd

Abstract

Schizophrenia is a debilitating disease that effects approximately 1% of the population with the onset of the disease occurring usually in the mid 20’s and persisting in many cases for the lifetime of the patient. Researchers have hypothesised that schizophrenia is due to excessive limbic dopaminergic function within the brain (Jaber et al 1996).

Keywords

Lone Pair Atypical Antipsychotic Pharmacophore Model Formal Thought Disorder Nitrogen Lone Pair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Bibliography

  1. Goodford, P.J., 1984, A computational procedure for determining energetically favourable binding sites on biologically important macromolecules. J. Med. Chem. 28, 849–57.CrossRefGoogle Scholar
  2. Jaber, S.W. Robinson, Missale, C., Caron M.G., 1996, Review: Dopamine receptors and brain function. Neuropharmacology, 35: 1503–1519CrossRefGoogle Scholar
  3. Liao, Y.; DeBoer, P.; Meirer, E.; Wikstrom, H., 1997, Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic. J. Med. Chem 40, 4146–53.CrossRefGoogle Scholar
  4. Liljefors, T., Pettersson, I., 1997, “Computer aided development of three-dimensional pharmacophore models”. A Textbook of Drug Design and Development, Larson, P.K.; Liljefors, T.; Madsen, U. (editors), Publisher, Harwood Academic.Google Scholar
  5. Petcher, T.J., 1995, “Topology of dopamine receptors” in The Role of Brain Dopamine Fluckiger, E., Muller, E.E., Thonier, M.O., (Editors), Publisher, Springer Sandoz.Google Scholar
  6. Schmidt, C.J., Sorensen, S.M., Kehne, J.H., Carr, A.A., Palfreyman M.G., 1995, Minireview: The role of 5HT2A receptors in antipsychotic activity. Life Sciences, 56: 2209–2222CrossRefGoogle Scholar
  7. Waddington, J.L., O’Callaghan, E., 1997, What makes an antipsychotic atypical? Conserving the defmition. CNS Drugs, 7: 341–6CrossRefGoogle Scholar
  8. Schotte, P.F.M., Janssen, W., Gommeren, W.H.M.L., Luyten, P., Van Gompel, A.S., Lesage, De Loore K., Leysen J.E., 1996, Risperidone compared with new and reference anti-psychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology, 124: 57–73.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Benjamin G. Tehan
    • 1
  • Margaret G. Wong
    • 1
  • Graeme J. Cross
    • 2
  • Edward J. Lloyd
    • 3
  1. 1.Chemistry DepartmentSwinburne University of TechnologyAustralia
  2. 2.Water CentreMonash UniversityAustralia
  3. 3.Medicinal Chemistry DepartmentVictorian College of Pharmacy, Monash UniversityAustralia

Personalised recommendations