Atypical Antipsychotics: Modelling and QSAR

  • Benjamin G. Tehan
  • Margaret G. Wong
  • Graeme J. Cross
  • Edward J. Lloyd


Schizophrenia is a debilitating disease that effects approximately 1% of the population with the onset of the disease occurring usually in the mid 20’s and persisting in many cases for the lifetime of the patient. Researchers have hypothesised that schizophrenia is due to excessive limbic dopaminergic function within the brain (Jaber et al 1996).


Lone Pair Atypical Antipsychotic Pharmacophore Model Formal Thought Disorder Nitrogen Lone Pair 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Benjamin G. Tehan
    • 1
  • Margaret G. Wong
    • 1
  • Graeme J. Cross
    • 2
  • Edward J. Lloyd
    • 3
  1. 1.Chemistry DepartmentSwinburne University of TechnologyAustralia
  2. 2.Water CentreMonash UniversityAustralia
  3. 3.Medicinal Chemistry DepartmentVictorian College of Pharmacy, Monash UniversityAustralia

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