Microvasculature of the Ovary

  • Akio Kikuta
  • Guido Macchiarelli
  • Takuro Murakami
Part of the Electron Microscopy in Biology and Medicine book series (EMBM, volume 9)


Oocyte development and hormone secretion are mutually related functions of the ovary. Oocytes develop and mature within developing follicles. Ovarian hormones are secreted from the stromal intersitial tissue, follicle, and corpora lutea, which are transformed from postovulatory follicles. The follicles, corpora lutea, and stroma compose the cortex of the ovary, and appear during the estrous cycle as successively transforming structures accompanied by very dynamic and continuous changes of their microvascular systems, including active angiogenesis, reconstruction, and degeneration of vessels.


Corpus Luteum Primordial Follicle Corpus Luteum Atretic Follicle Preovulatory Follicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Clark JC: The origin, development and degeneration of the blood vessels of the human ovary. Bull Johns Hopkins Hosp 9: 593–676, 1900.Google Scholar
  2. 2.
    Delson B, Lubin S, Reynolds SRM: Vascular patterns in human ovaries. Am J Obstet Gynecol 57: 842–853, 1949.PubMedGoogle Scholar
  3. 3.
    Gillet JY: Etudes anatomo-physiologiques. La microvascularisation de l’ovaire. Gynecol Obstet 70: 251–272, 1971.Google Scholar
  4. 4.
    Basset DL: The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle. Am J Anat 73: 251–291, 1943.CrossRefGoogle Scholar
  5. 5.
    Burr JH, Davies JI: The vascular system of the rabbit ovary and its relationship to ovulation. Anat Rec 111:273–297, 1951.PubMedCrossRefGoogle Scholar
  6. 6.
    Murakami T: Application of the scanning electron microscope to the study of fine distribution of the blood vessels. Arch Histol Jpn 32: 445–454, 1971.PubMedCrossRefGoogle Scholar
  7. 7.
    Kardon RH, Kessel KG: SEM studies on vascular casts of the rat ovary. Scanning Electron Microsc 3: 743–750, 1979.Google Scholar
  8. 8.
    Kikuta A, Ohtsuka A, Ohtani O, Murakami T: Microvascularization of endocrine glands as studied by injection-replica SEM method. In: Motta PM (ed), Ultrastructure of Endocrine Cells and Tissues. Boston: Martinus Nijhoff, pp. 314–320, 1984.Google Scholar
  9. 9.
    Takada S, Shimada T, Nakamura M, Mori H, Kigawa T: Vascular pattern of the mammalian ovary with special reference of the three-dimensional architecture of the spiral artery. Arch HistolJpn 50: 407–418, 1987.CrossRefGoogle Scholar
  10. 10.
    Murakami T, Ikebuchi Y, Ohtsuka A, Kikuta A, Taguchi T, Ohtani O: The blood vascular wreath of rat ovarian follicle, with special reference to its changes in ovulation and luteinization: A scanning electron microscopic study of corrosion casts. Arch Histol Cytol 51: 299–313, 1988.PubMedCrossRefGoogle Scholar
  11. 11.
    Kanzaki H, Okamura H, Okuda Y, Takenaka A, Morimoto K, Nishimura T: Scanning electron microscopic study of rabbit ovarian follicle microvasculature using resin injection-corrosion casts. J Anat 134: 697–704, 1982.PubMedGoogle Scholar
  12. 12.
    Kitai H, Yoshimura Y, Write KH, Santulli R, Wallach EE: Microvasculature of preovulatory follicles: Comparison of in situ and in vitro perfused rabbit ovaries following stimulation of ovulation. Am J Obstet Gynecol 152: 889–895, 1985.PubMedGoogle Scholar
  13. 13.
    Hees H, Koenig HE, Hees I: Recherches sur la structure vasculaire du systeme de vaisseaux sanguins des structures elaborées au cours du cycle ovarien chez la jument. Une recherche au microscpe optique et au microscope a balayage electronique. Contracept Fertil Sex 16: 521–526, 1988.Google Scholar
  14. 14.
    Konig HE, Amselgruber W, Russe I: La microcirculation dans les follicles et les corps jaunes d’ovaires de bovins. Une etude anatomique par corrosion. Contracept Fertil Sex 17: 179–186, 1989.Google Scholar
  15. 15.
    Mapletoft RJ, Ginther OJ: Adequacy of main uterine vein and the ovarian artery in the local venoarterial pathway for uterine-induced luteolysis in ewes. Am J Veter Res 36: 957–963, 1975.Google Scholar
  16. 16.
    McCrachen JA, Carlson JC, Glew ME, Goding JR Baird DT, Green K, Samuelsson B: Prostaglandin F2-alpha identified as luteolytic hormone in sheep. Nature New Biol 238: 129–134, 1972.CrossRefGoogle Scholar
  17. 17.
    Henderson JR, Daniel PM: Portal circulations and their relation to countercurrent systems. QJ Exp Physiol 63: 355–369, 1978.Google Scholar
  18. 18.
    Heap RB, Fleet IR, Hamon M: Prostaglandin F2-alpha, is transferred from the uterus to the ovary in the sheep by lymphatic and blood vascular pathways. J Reprod Fertil 74: 645–656, 1985.PubMedCrossRefGoogle Scholar
  19. 19.
    Andersen DH: Lymphatics and blood vessels of the ovary of the sow. Contrib Embryol Carnegie Inst 17: 107–123, 1926.Google Scholar
  20. 20.
    Reynolds SRM: The vasculature of the ovary and ovarian function. Recent Progr Hormone Res 5: 65–100, 1950.Google Scholar
  21. 21.
    Reynolds SRM: Blood and lymph vascular systems of the ovary. In: Greep RD, Astwood EB (eds), Handbook of Physiology-Endocrinology II, Part 1. Washington DC: Am Physiol Soc, pp. 261–316, 1973.Google Scholar
  22. 22.
    Blasco L, Wu CH, Flickinger GL, Wheller J, Mikhail G: Blood flow to the reproductive organs of the estrous rabbit. Gynecol Invest 4: 270–276, 1973.CrossRefGoogle Scholar
  23. 23.
    Gillet JY, Maillet R, Gautier C: Blood and lymph supply of the ovary. In: Motta PM, Hafez ESE (eds), Biology of the Ovary. The Hague: Martinus Nijhoff, pp. 86–98, 1980.CrossRefGoogle Scholar
  24. 24.
    Duke KL: Nonfollicular ovarian component. In: Jones RE (ed), The Vertebrate Ovary. Comparative Biology and Evolution. New York: Plenum Press, pp. 563–582, 1978.Google Scholar
  25. 25.
    Motta PM: Osservazioni sulla fine struttura delle cellule interstiziali dell’ovaio. Biologica Latina 18: 107–137, 1966.Google Scholar
  26. 26.
    Davies J, Broads CD: Studies on the fine structure of ovarian steroid-secreting cells in the rabbit I. The normal interstitial cells. Am J Anat 123: 441–447, 1968.PubMedCrossRefGoogle Scholar
  27. 27.
    Guraya SS, Motta PM: Interstitial cells and related structures. In: Motta PM, Hafez ESE (eds), Biology of the Ovary. The Hague: Martinus Nijhoff, pp. 68–85, 1980.CrossRefGoogle Scholar
  28. 28.
    Guraya SS, Greenwald GS: Histochemical studies on the interstitial gland in the rabbit ovary. Am J Anat 114: 495–520, 1964.PubMedCrossRefGoogle Scholar
  29. 29.
    Greenwald GS, Terranova PF: Follicular selection and its control. In: Knobil E, Neill J (eds), The Physiology of Reproduction. New York: Raven Press, pp. 387–445, 1988.Google Scholar
  30. 30.
    Morris B, Sass MB: The formation of lymph in the ovary. Proc R Soc London 164: 577–591, 1966.CrossRefGoogle Scholar
  31. 31.
    Boling JL, Blandau RJ, Soderwall AR, Young WC: Growth of the Graafian follicle and the time of ovulation in the albino rat. Anat Rec 79: 313–331, 1941.CrossRefGoogle Scholar
  32. 32.
    Kranzfelder D, Korr H, Mestwerdt W, Maurer-Schultze B: Follicle growth in the ovary of the rabbit after ovulation inducing application of human chorionic gonadotropin. Cell Tissue Res 238: 611–620, 1984.PubMedCrossRefGoogle Scholar
  33. 33.
    Spanel-Borowsky K, Amselgruber W, Sinowatz F: Capillary sprouts in ovaries of immature superstimulated golden hamster: A SEM study of microcorrosion casts. Anat Embryol 176: 387–391, 1987.CrossRefGoogle Scholar
  34. 34.
    Hay MF, Cran DG, Moor RR: Structural changes occuring during atresia in sheep ovarian follicles. Cell Tissue Res 169: 515–529, 1976.PubMedCrossRefGoogle Scholar
  35. 35.
    Biskov AG: Follicular atresia. In: Jones RE (ed), The Vertebrate Ovary. Comparative Biology and Evolution. New York: Plenum Press, pp. 533–561, 1978.Google Scholar
  36. 36.
    Motta PM, Familiari G: Occurrence of a contractile tissue in the theca externa of atretic follicles in the mouse ovary. Acta Anat 109: 103–114, 1981.PubMedCrossRefGoogle Scholar
  37. 37.
    Mossmann HW, Duke KL: Comparative Morphology of the Mammalian Ovary. Madison, WI: University of Wisconsin Press, 1973.Google Scholar
  38. 38.
    Espey LL: Ultrastructure of the apex of the rabbit Graafian follicle during the ovulatory process. Endocrinology 81: 267–276, 1967.PubMedCrossRefGoogle Scholar
  39. 39.
    Motta PM, Cherney DD, DiDio LJA: Scanning and transmission electron microscopy of the ovarian surface in mammals with special reference to ovulation. J Submicrosc Cytol 3: 85–100, 1971.Google Scholar
  40. 40.
    Cherney DD, DiDio LJA, Motta PM: The development of rabbit ovarian follicles following copulation. Fertil Steril 26: 257–270, 1975.PubMedGoogle Scholar
  41. 41.
    Motta PM, Van Blerkom J: A scanning electron microscopy study of the luteo-follicular complex. II. Events leading to ovulation. Am J Anat 143: 241–264, 1975.PubMedCrossRefGoogle Scholar
  42. 42.
    Bjersing L, Cajander S: Ovulation and the mechanism of follicle rupture. VI. Ultrastructure of theca interna and the inner vascular network surrounding rabbit Graafian follicles prior to induced ovulation. Cell Tissue Res 153: 31–44, 1974.PubMedCrossRefGoogle Scholar
  43. 43.
    Okuda Y, Okamura H, Kanzaki H, Takenaka A, Morimoto K, Nishimura T: An ultrastructural study of capillary permeability of rabbit ovarian follicles during ovulation using carbon tracer. Acta Obstet Gynecol Jpn 32: 859–867, 1980.Google Scholar
  44. 44.
    Blandau RJ: Ovulation in the living albino rat. Fertil Steril 6: 391–404, 1955.PubMedGoogle Scholar
  45. 45.
    Ichikawa D, Uchino S, Hirata Y: Lymphatic and blood vasculature of the forming corpus luteum. Lymph-ology 20: 73–83, 1987.Google Scholar
  46. 46.
    Boling JL: Growth and regression of corpora lutea during the normal estrous cycle of the rat. Anat Rec 82: 131–145, 1942.CrossRefGoogle Scholar
  47. 47.
    Pharriss BB: The possible vascular regulation of luteal function. Perspect Biol Med 13: 434–444, 1970.PubMedGoogle Scholar
  48. 48.
    Goding JR, Baird DT, Cumming IA, McCracken JA: Functional assessment of autotransplanted endocrine glands. Acta Endocrinol 158 (Suppl:) 169–191, 1972.Google Scholar
  49. 49.
    Niswender GD, Reimers TJ, Diekman MA, Nett TM: Blood flow: A mediator of ovarian function. Biol Reprod 14: 64–81, 1976.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Akio Kikuta
    • 1
  • Guido Macchiarelli
  • Takuro Murakami
  1. 1.Department of AnatomyOkayama University Medical SchoolOkayamaJapan

Personalised recommendations