Vaccinia Virus and Dendritic (Langerhans) Cells: Need for Elucidation of the Role of Dendritic Cells in Vaccination
In the review on smallpox by Behbahani (1) it is indicated that Edward Jenner used materials from individuals infected with cowpox or horsepox (grease) for immunization. The live vaccines subsequently used were produced from four basic strains: a) The Lister Institute or Elstree strain in the United Kingdom that originated from a Prussian soldier with smallpox during the 1870 Franco-Prussian war and was introduced into Britian from Cologne as calf lymph in 1907, b) the Wyeth or the New York Board strain in the United States of America that was started in 1876 from an unidentified vaccine imported from Britain in the 1850s, c) the EMG 3 strain in the USSR which was derived from a commercial vaccine of unknown origin from Ecuador, and d) a vaccine strain strain designated Tian Tan strain that is being used in China.
KeywordsDendritic Cell Vaccinia Virus Recombinant Vaccinia Virus Smallpox Vaccination Smallpox Vaccine
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