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High Levels of Circulating Hematopoietic Progenitor Cells after Continuous Infusion of High Dose Interleukin-2 in Cancer Patients

  • M. R. Schaafsma
  • J. H. F. Falkenburg
  • N. Duinkerken
  • D. van der Harst
  • A. Brand
  • S. Osanto
  • C. R. Franks
  • R. Willemze
  • W. E. Fibbe
Part of the Developments in Hematology and Immunology book series (DIHI, volume 25)

Abstract

Over the past few years recombinant human interleukin-2 (IL-2), with or without infusion of in vitro generated lymphokine-activated killer (LAK) cells, has been administered to patients with disseminated cancer for its antitumor activity [1]. It has been demonstrated that this treatment is accompanied by various hematologic side effects, including anemia, thrombocytopenia, eosinophilia and lymphopenia, followed by a rebound lymphocytosis after discontinuation of IL-2 infusion [2,3]. Little is known, however, about the effects of IL-2 administration on the in vivo proliferation of hematopoietic progenitor cells (HPC). In mice, Talmadge et al [4] showed that the number of myeloid progenitor cells (CFU-GM) in bone marrow increased during IL-2 treatment, probably secondary to the induction of GM-CSF and IL-3. In humans, Ettinghausen et al [3] reported decreased numbers of circulating HPC during IL-2 treatment, suggesting an inhibitory effect of IL-2 on hematopoiesis. One of the patients in their study, however, showed a strong increase in the number of circulating progenitor cells after discontinuation of IL-2 therapy.

Keywords

Peripheral Blood Stem Cell Hematopoietic Progenitor Cell Autologous Transplantation Hemopoietic Stem Cell Autologous Peripheral Blood Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • M. R. Schaafsma
  • J. H. F. Falkenburg
  • N. Duinkerken
  • D. van der Harst
  • A. Brand
  • S. Osanto
  • C. R. Franks
  • R. Willemze
  • W. E. Fibbe

There are no affiliations available

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