Parathyroid Hormone and the Myocardiopathy of Chronic Renal Failure

  • Shaul G. Massry
  • Miroslaw Smogorzewski
  • Alessandra F. Perna
Part of the Topics in Renal Medicine book series (TIRM, volume 10)


Patients with advanced chronic renal failure (CRF) and those treated with dialysis display a large number of cardiovascular complications. These are listed in table 9–1. These patients may suffer from myocardial disease [1–6], and several factors have been implicated in its genesis (table 9–2). These include anemia, electrolyte disturbances, acidosis, and hypertension [5–7]. Accelerated atherogenesis has also been suggested as the cause of myocardial disease in many of these patients [8]. Drueke et al. [9] reported that 7 of 21 hemodialysis patients with congestive myocardiopathy did not have angiographic evidence of coronary artery disease or other causes for the myocardiopathy. Others [6] also reported myocardiopathy of unexplained etiology, and the cardiac disease was attributed to “ uremic toxins,” but the nature and characteristics of a uremic toxin that acts on the myocardium were not identified.


Parathyroid Hormone Chronic Renal Failure Secondary Hyperparathyroidism Heart Cell Uremic Toxin 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Shaul G. Massry
  • Miroslaw Smogorzewski
  • Alessandra F. Perna

There are no affiliations available

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