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The Role of Calcium in Coagulation and Anticoagulation

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Coagulation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 26))

Abstract

The quality of the coagulation-related blood-derived products is markedly affected by the manner in which blood is collected. Standard anticoagulation solutions contain citrate which efficiently prevents blood clotting by chelation of calcium and other metal ions. However, there are two sides to the matter, which is often overlooked. For instance,chelation of calcium leads to conformational changes of the coagulation factors V and VIII which results in loss of the procoagulant activity.

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© 1991 Springer Science+Business Media Dordrecht

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Mikaelsson, M.E. (1991). The Role of Calcium in Coagulation and Anticoagulation. In: Sibinga, C.T.S., Das, P.C., Mannucci, P.M. (eds) Coagulation and Blood Transfusion. Developments in Hematology and Immunology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3900-1_3

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  • DOI: https://doi.org/10.1007/978-1-4615-3900-1_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6740-6

  • Online ISBN: 978-1-4615-3900-1

  • eBook Packages: Springer Book Archive

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