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The Role of Calcium in Coagulation and Anticoagulation

Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 26)

Abstract

The quality of the coagulation-related blood-derived products is markedly affected by the manner in which blood is collected. Standard anticoagulation solutions contain citrate which efficiently prevents blood clotting by chelation of calcium and other metal ions. However, there are two sides to the matter, which is often overlooked. For instance,chelation of calcium leads to conformational changes of the coagulation factors V and VIII which results in loss of the procoagulant activity.

Keywords

Factor VIII Coagulation Factor VIII Coagulation Factor Versus Human Factor VIII Prevent Blood Clotting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media Dordrecht 1991

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