The Role of Calcium in Coagulation and Anticoagulation

Part of the Developments in Hematology and Immunology book series (DIHI, volume 26)


The quality of the coagulation-related blood-derived products is markedly affected by the manner in which blood is collected. Standard anticoagulation solutions contain citrate which efficiently prevents blood clotting by chelation of calcium and other metal ions. However, there are two sides to the matter, which is often overlooked. For instance,chelation of calcium leads to conformational changes of the coagulation factors V and VIII which results in loss of the procoagulant activity.


Factor VIII Coagulation Factor VIII Coagulation Factor Versus Human Factor VIII Prevent Blood Clotting 
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© Springer Science+Business Media Dordrecht 1991

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