Clinical Efficacy of Clotting Factor Concentrates: Survival, Recovery and Hemostatic Capacity
Factor VIII concentrates are necessary for the treatment not only of patients with hemophilia A but also for those with severe von Willebrand’s disease (vWD), especially the type III or the type II variants. Earlier, above all cryoprecipitate, and low and intermediate purity concentrates were used. The intermediate purity concentrates contained 1–3 units of factor VIII clotting activity (FVIII:C) per mg protein, factor VIII itself being only a trace protein. Since 1984, all commercial factor VIII concentrates have been subjected to some form of virus inactivation.In the last years several plasma-derived, superpure factor VIII concentrates have been developed to eliminate the risk of viral transmission, and to reduce other side effects caused by the multiplicity of foreign proteins and alloantigens the concentrates of intermediate purity contain. Clinical trials of recombinant factor VIII have also been started. Correction of the bleeding defect in vWD requires a concentrate containing almost native von Wille rand factor (vWF).
KeywordsAlbumin Steam Recombinate Agarose Citrate
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