Skip to main content
SpringerLink
Log in

Thermochemotherapy for Soft Tissue Sarcomas

  • Chapter
Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment

Part of the book series: Cancer Treatment and Research ((CTAR,volume 56))

Abstract

Many years ago, several in vitro and in vivo experimental studies demonstrated the selective heat sensitivity of cancer cells. The first clinical applications of hyperthermia then confirmed its effectiveness for treating cancer [1–5].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Busch W: Uber den einfluss welchen heftiger erysipelen zuweilen auf organisierte Neubildungen aushen. Verhandlungen des Naturhistorischer. Vereins Preussicher Rheinaids West-phalen 23:28–30, 1866.

    Google Scholar 

  2. Coley WB: The treatment of malignant tumors by repeated inoculations of erysipelas with a report of original cases. Ann J Med Sci 105:487–511, 1893.

    Article  Google Scholar 

  3. Rohdenburg GL et al.: The effect of combined radiation and heat on neoplasms. Arch Surg 2:1548–1554, 1906.

    Google Scholar 

  4. Warren SL: Preliminary study on the effect of artificial fever upon hopeless tumor cases. AJR 33:75–87, 1935.

    Google Scholar 

  5. Cavaliere R et al.: Selective heat sensitivity of cancer cells: Biochemical an clinical studies. Cancer 20:135–1381, 1967.

    Article  Google Scholar 

  6. Hunt JW: Applications of microwaves, ultrasounds and radio frequencies heating in vivo. In: Proceedings of the Third International Symposium on Cancer Therapy by Hyperther-mia, Drugs and Radiation. Dethlefsen LA, Dewey WC (eds). Bethesda, MD: pp 447–456, 1984.

    Google Scholar 

  7. Weisser M et al.: Advanced technique in localized current field hyperthermia. Recent Results Cancer Res 107:87–92, 1988.

    Article  PubMed  CAS  Google Scholar 

  8. Gerner EW: Thermotolerance. In: Hyperthermia in cancer therapy. Storm FK (ed). Boston: GK Hall, pp 141–162, 1983.

    Google Scholar 

  9. Field SB et al.: Thermotolerance: A review of observations and possible mechanisms. Natl Cancer Inst Monogr 61:193–201, 1982.

    PubMed  CAS  Google Scholar 

  10. Cavaliere R et al.: Regional perfusion hyperthermia. In: Hyperthermia in cancer therapy. Storm FK (ed). Boston: GK Hall, pp 369–399, 1983.

    Google Scholar 

  11. Bull JMC: An update on anticancer effects of a combination of chemotherapy and hyperthermia. Cancer Res 44 (Suppl):4853–4856, 1984.

    Google Scholar 

  12. Bicher HI et al.: Clinical thermoradiotherapy. In: Hyperthermia in cancer therapy. Storm FK (ed). Boston: GK Hall, 1987.

    Google Scholar 

  13. Overgaard J: Combined hyperthermia and radiation treatment of malignant melanoma. In: Hyperthermic oncology 1988. Sugohare T, Saito M (eds). London: Taylor-Francis, pp 464–468, 1988.

    Google Scholar 

  14. Arcangeli G: Analysis of results in neck node metastases from tumors of the head and neck. Recent Results Cancer Res 107:118–122, 1988.

    Article  PubMed  CAS  Google Scholar 

  15. Hahn GM: Hyperthermia and cancer. New York: Plenum, pp 74–85, 1982.

    Book  Google Scholar 

  16. Hahn GM et al.: Thermochemotherapy: Synergism between hyperthermia (42-43 C°) and adriamycin (or bleomycin) in mammalian cell inactivation. Proc Natl Acad Sci USA 12:937–940, 1975.

    Article  Google Scholar 

  17. Hahn GM: Potential for therapy of drugs and hyperthermia. Cancer Res 39:2264–2268, 1979.

    PubMed  CAS  Google Scholar 

  18. Moricca G et al.: Hyperthermic treatment of tumors: Experimental and clinical applications. Recent Results Cancer Res 59:112–151, 1977.

    PubMed  Google Scholar 

  19. Li GC et al.: Correlation between synthesis of heat shock proteins and development of thermoresistence in Chinese hamster fibroblasts. Proc Natl Acad Sci USA 79:3219–3222, 1982.

    Google Scholar 

  20. Tomasovic SP et al.: Heat stress proteins and thermal resistence in rat mammary tumor cells. Radiat Res 70:610–611, 1977.

    Google Scholar 

  21. Reinhold HS et al.: Enhancement of thermal damage to sandwich tumors by additional treatment. In: Proceedings of the First Meeting of the European Group on Hyperthermia in Radiation Oncology, Arcangeli G, Mauro F (eds). Milan: Masson, pp 179–183, 1980.

    Google Scholar 

  22. Kim JH et al.: Lonidamine: A hyperthermic sensitizer of HeLa cells in culture and of Meth-A tumor in vivo. Oncology 41(Suppl 1):30–35, 1984.

    Article  PubMed  CAS  Google Scholar 

  23. Kim JH et al.: Quercitin, an inhibitor of lactate transport and hyperthermic sensitizer of HeLa cells. Cancer Res 44:1165–1168, 1980.

    Google Scholar 

  24. Barlogie B et al.: In vitro thermochemotherapy of human colon cancer cells with CDDP and mytomicin C. Cancer Res 40:1165–1162, 1980.

    PubMed  CAS  Google Scholar 

  25. Herman TS: Effect of temperature on the cytotoxicity of vindesine, amsacrine and mitoxan-trone. Cancer Treat Rep 67:1019–1022, 1983.

    PubMed  CAS  Google Scholar 

  26. Johnson HA et al.: Thermal enhancement of thiotepa cytotoxicity. J Natl Cancer Inst 50:903–908, 1973.

    PubMed  CAS  Google Scholar 

  27. Jirtle RL: Chemical modification of tumor blood flow. Int J Hyperthermia 4:355–372, 1988.

    Article  PubMed  CAS  Google Scholar 

  28. Dahl O: Interaction of hyperthermia and chemotherapy. Recent Results Cancer Res 107:157–169, 1988.

    Article  PubMed  CAS  Google Scholar 

  29. Teicher BA et al.: Enhancement by hyperthermia of the in vitro cytotoxicity of mytomicin C toward hypoxic tumor cells. Cancer Res 41:1096–1099, 1981.

    PubMed  CAS  Google Scholar 

  30. Clawson RE et al.: Hyperthermic modification of cyclophosphamide metabolism in rat hepatic microsomes and liver slices. Life Sci 28:1133–1137, 1981.

    Article  PubMed  CAS  Google Scholar 

  31. Wallner KE et al.: Hyperthermic potentiation of cis-diammine dichloroplatinum (II) cytotoxicity in Chinese hamster ovary cells resistant to the drug. Cancer Res 46:6242–6245, 1986.

    PubMed  CAS  Google Scholar 

  32. Alberts DS et al.: Therapeutic synergism of hyperthermia-cis-platinum in a mouse tumor model. J Natl Cancer Inst 65:455–461, 1980.

    PubMed  CAS  Google Scholar 

  33. Meyn RE et al.: Thermal enhancement of DNA strand breakage in mammalian cells treatment with bleomycin. Int J Radiat Oncol Biol Phys 5:1487–1489, 1979.

    Article  PubMed  CAS  Google Scholar 

  34. Kubota Y et al.: Effect of hyperthermia on DNA single strand breaks induced by bleomycin in HeLa cells. Gann 70:681–685, 1979.

    PubMed  CAS  Google Scholar 

  35. Smith PJ et al.: Interaction between bleomycin, hyperthermia and calmodulin inhibitor (trifluoperazine) in mouse tumor cells. II. DNA damage, repair and chromatin changes. Br J Cancer 53:105–114, 1986.

    Article  PubMed  CAS  Google Scholar 

  36. Djordjevic O et al.: The combined effects of hyperthermia and a chemotherapeutic agent on DNA in isolated mammalian cells. In: Cancer therapy by hyperthermia and radiation. Streffer C et al. (eds). Munich: Urban and Schwarzenberg, pp 278–280, 1978.

    Google Scholar 

  37. Johnson HA et al.: Thermal enhancement of thio-tepa cytotoxicity. J Natl Cancer Inst 50:903–908, 1973.

    PubMed  CAS  Google Scholar 

  38. Spiro IJ et al.: Effect of hyperthermia on CHO DNA polymerase alfa and beta. Radiation Res 89:134–149, 1982.

    Article  PubMed  CAS  Google Scholar 

  39. Arrick BA, Nathan CF: Glutathione metabolism as a determinant of therapeutic efficacy: A review. Cancer Res 44:4224–4232, 1984.

    PubMed  CAS  Google Scholar 

  40. Shrieve DC et al.: Cellular glutathione, thermal sensitivity and thermotolerance in Chinese hamster fibroblasts and their heat-resistant variants. Cancer Res 46:1684–1687, 1986.

    PubMed  CAS  Google Scholar 

  41. Joiner MC et al.: Response of two mouse tumors to hyperthermia with CCNU or melpha-lan. Br J Cancer 45:19–26, 1982.

    Article  Google Scholar 

  42. Leeds DE et al.: Internal organ hypoxia during hyperthermic cancer therapy in humans. Proceedings of the Third International Symposium on Cancer Therapy by Hyperthermic Drugs and Radiation, Fort Collins, CO, p 3, 1980.

    Google Scholar 

  43. Bleehn NM et al.: Interaction of hyperthermia and the hypoxic cells sensitizer. RO-07-0582 in the EMT6 mouse tumor. Br J Cancer 35:299–306, 1977.

    Article  Google Scholar 

  44. Kapp DS et al.: Thermosensitization by sulphydril compounds of exponentially growing Chinese hamster cells. Cancer Res 29:4630–4635, 1977.

    Google Scholar 

  45. Robins IH et al.: Systemic lidocaine enhancement of hyperthermia-induced tumor regression in transplantable murine tumor models. Cancer Res 43:3187–3191, 1983.

    PubMed  CAS  Google Scholar 

  46. Herman TS et al.: Reversal of resistance to metothrexate hyperthermia in Chinese hamster ovary cells. Cancer Res 41:3840–3843, 1981.

    PubMed  CAS  Google Scholar 

  47. Marmor JE: Interaction of hyperthermia and chemotherapy on animals. Cancer Res 89:2269–2276, 1979.

    Google Scholar 

  48. Minmaugh EG et al.: Effect of W.B.H. on the deposition and metabolism of ADR in rabbits. Cancer Res 38:1420–1425, 1978.

    Google Scholar 

  49. Kuori M et al.: Antitumor effect of interferon combined with hyperthermia against experimental brain tumor. Proceedings of the Fifth International Symposium of Hyperthermia Oncology, Kyoto, Japan, Aug 29-Sept 3, 1988, pp 232–233.

    Google Scholar 

  50. Kallinowski F et al.: Effect of tumor necrosis factor alpha on tumor blood flow and hyperthermic treatment. Oncologie 12:131–135, 1989.

    Article  CAS  Google Scholar 

  51. Maeta M et al.: The effect of angiotensin II on blood flow in tumors during localized hyperthermia. Int J Hyperthermia 5:191–197, 1989.

    Article  PubMed  CAS  Google Scholar 

  52. Yamanchi N et al.: Antitumor synergism of recombinant human tumor necrosis factors and hyperthermia. Proceedings of the Fifth International Symposium of Hyperthermia Oncology, Kyoto, Japan, Aug 29-Sept 3, 1988, pp 282–284.

    Google Scholar 

  53. Yasue S et al.: On combination therapy of selective local hyperthermia and local immuno-modulator. Proceedings of the Fifth International Symposium of Hyperthermia Oncology, Kyoto, Japan, Aug 29-Sept 3, 1988, pp 234–235.

    Google Scholar 

  54. Greco C et al.: Effect of sequential hyperthermia and chemotherapy on the survival of a thermoresistant human melanoma cell line. Cancer Biochem Biophys 9:223–232, 1987.

    PubMed  CAS  Google Scholar 

  55. Di Filippo F et al.: Prognostic variables in recurrent limb melanoma treated with hyperthermia antiblastic perfusion. Cancer 63:2551–2561, 1989.

    Article  PubMed  Google Scholar 

  56. Marijnissen H et al.: Interstitial photodynamic therapy of rat rhabdomyosarcoma: Dose effect relationships. Seventh Annual Meeting of the European Society for Therapeutic Radiology and Oncology, Den Haag, The Netherlands, September 5–8, 1988, p 391.

    Google Scholar 

  57. Pfeffer HR et al.: Platinum distribution, retention and DNA cross-linking in tumors and normal tissue of mice treated with CDDP and local hyperthermia. Thirty-Seventh Annual Meeting of the Radiation Research Society and Ninth Annual Meeting of the North American Hyperthermia Group. March 18-23, 1989, Seattle, WA, p 27, 1989.

    Google Scholar 

  58. Nishiue T et al.: Studies on combination of hyperthermia and chemotherapy for cancer. Proceedings of the Fifth International Symposium of Hyperthermia Oncology, Kyoto, Japan, Aug 29-Sept 3, 1988.

    Google Scholar 

  59. George C et al.: Enhancement of hyperthermic response of a mouse fibrosarcoma by membrane specific drugs. Proceedings of the Fifth International Symposium of Hyperthermia Oncology Kyoto, Japan, Aug 29-Sept 3, 1988.

    Google Scholar 

  60. Baba H et al.: Effect of whole body hyperthermia combined with adriamycin on tumor and normal tissue in rats. Thirty-Seventh Annual Meeting of the Radiation Research Society and Ninth Annual Meeting of the North American Hyperthermia Group, March 18–23, 1989, Seattle, WA, p 34, 1989.

    Google Scholar 

  61. Milligan AJ: Whole body hyperthermia induction techniques. Cancer Res 44 (Suppl): 4869–4872, 1984.

    Google Scholar 

  62. Di Filippo F et al.: Role of hyperthermic perfusion as a first step in the treatment of soft tissue sarcoma of the extremities. World J Surg 12:332–339, 1982.

    Article  Google Scholar 

  63. Di Filippo F et al.: Hyperthermic perfusion with cisplatin: Standardization of treatment parameters. Regional Cancer Treat 2:131–136, 1989.

    Google Scholar 

  64. Lehti PM et al.: Improved survival for soft tissue sarcoma of the extremities by regional hyperthermic perfusion, local excision and radiation therapy. Surg Gynecol Obstet 162:142–152, 1986.

    Google Scholar 

  65. Stehlin JS et al.: 15-Year experience with hyperthermic perfusion for treatment of soft tissue sarcoma and malignant melanoma of the extremities. In: Hyperthermia and radiation therapy/chemotherapy in the treatment of cancer. Vaeth JM (ed). San Francisco: pp 177–182, 1984.

    Google Scholar 

  66. Jabboury K et al.: Local hyperthermia for resistant soft tissue sarcoma. Thirty-Fourth Annual Meeting of the Radiation Research Society, Las Vegas, April 1986, p 18.

    Google Scholar 

  67. Issels R et al.: Regional hyperthermia combined with systemic chemotherapy. Fourth Internation Conference on Advances in Regional Cancer Therapy, June 5-7, 1989, Berchtessgaden, 1989.

    Google Scholar 

  68. Cavaliere R: Unpublished data.

    Google Scholar 

  69. Storm FK et al.: Magnetic induction hyperthermia: Results of a five-year multiinstitutional national cooperative trial in advanced cancer patients. Cancer 55:2677–2687, 1985.

    Article  PubMed  CAS  Google Scholar 

  70. Gerard H et al.: Doxorubicin, cyclophosphamide and WBH for treatment of advanced soft tissue sarcomas. Cancer 53:2585–2591, 1984.

    Article  Google Scholar 

  71. Cantin J et al.: The problem of local recurrence after treatment of soft tissue sarcoma. Ann Surg 168:47–53, 1968.

    Article  PubMed  CAS  Google Scholar 

  72. Heise HW et al.: Recurrence-free survival time for surgically treated soft tissue sarcoma patients: Multivariate analysis of five prognostic factors. Cancer 57:172–177, 1986.

    Article  PubMed  CAS  Google Scholar 

  73. Cruz AB et al.: Combination chemotherapy for soft tissue sarcoma: A phase II study. J Surg Oncol 11:313–323, 1979.

    Article  PubMed  Google Scholar 

  74. Greenhall MS et al.: Chemotherapy for soft tissue sarcoma. Surg Gynecol Obstet 162:193–198, 1986.

    Google Scholar 

  75. Verweij J, Pinedo HM: Chemotherapy in advanced soft tissue sarcoma. In: Clinical management of soft tissue sarcoma Pinedo HM, Verweij J (eds). Boston: Martinus Nijhoff, pp 81–88, 1986.

    Chapter  Google Scholar 

  76. Chang AE et al.: Sarcomas of the soft tissue. In: Cancer: Principles and practice of oncology. De Vita VT, Hellman S, Rosenberg SA (eds). Philadelphia: JB Lippincott, pp 1345–1398, 1989.

    Google Scholar 

  77. Rosenberg SA: Prospective randomized trials demonstrating the efficacy of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities. Cancer 52:424–434, 1983.

    Article  PubMed  CAS  Google Scholar 

  78. Gherlinzoni F et al.: A randomized trial for the treatment of high-grade soft tissue sarcomas of the extremities: Preliminary observations. J Clin Oncol 4:552–558, 1986.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. F. Di Filippo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Botti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Giannarelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Graziano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Carlini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. Cavaliere
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Cavaliere
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands

    Herbert M. Pinedo

  2. Department of Medical Oncology, Rotterdam Cancer Institute, Rotterdam, The Netherlands

    Jaap Verweij

  3. Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Herman D. Suit

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Di Filippo, F. et al. (1991). Thermochemotherapy for Soft Tissue Sarcomas. In: Pinedo, H.M., Verweij, J., Suit, H.D. (eds) Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment. Cancer Treatment and Research, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3896-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3896-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6738-3

  • Online ISBN: 978-1-4615-3896-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation