Oxidative Substrate Metabolism in Reperfused Myocardium
The oxidative metabolic rate in retrogradely perfused isolated rat hearts is exceedingly high relative to contractile performance early after postischemic reperfusion. This hypermetabolism is not only observed in hearts that were reversibly “stunned” but also in hearts that were irreversibly injured after one hour of reperfusion. The dissociation between contractile function and oxygen consumption decreases during administration of ruthenium red, compatible with the involvement of mitochondrial calcium transport in the mechanisms of postischemic hypermetabolism.
KeywordsPlacebo Ischemia Albumin Respiration Radionuclide
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