Oxidative Substrate Metabolism in Reperfused Myocardium

  • Rene Lerch
  • Gunter Goerge
  • Richard Benzi
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 121)

Abstract

The oxidative metabolic rate in retrogradely perfused isolated rat hearts is exceedingly high relative to contractile performance early after postischemic reperfusion. This hypermetabolism is not only observed in hearts that were reversibly “stunned” but also in hearts that were irreversibly injured after one hour of reperfusion. The dissociation between contractile function and oxygen consumption decreases during administration of ruthenium red, compatible with the involvement of mitochondrial calcium transport in the mechanisms of postischemic hypermetabolism.

Keywords

Placebo Ischemia Albumin Respiration Radionuclide 

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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • Rene Lerch
  • Gunter Goerge
  • Richard Benzi

There are no affiliations available

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