The Effects of Potassium on Anisotropic Conduction
A cryo-technique was used to create a thin layer of perfused anisotropic epicardium in Langendorff perfused rabbit hearts. The heart was stimulated with a frequency of 0.5 Hz and the extracellular concentration of K+ was gradually increased. The resulting effects on anisotropic conduction were studied by using a high resolution mapping system. In this setting, no preferential effect of K+ on the ratio of anisotropy or on the occurrence of local conduction block could be detected.
KeywordsAnisotropy Depression Ischemia MgCl CaCl
Unable to display preview. Download preview PDF.
- 3.Schalij MJ: Anisotropic conduction and ventricular arrhythmias. PhD Thesis, University of Limburg, 1988.Google Scholar
- 7.Delmar M, Delgado C, Chialvo D, Michaels DC, Jalife J: On the problem of anisotropic propagation in ventricular muscle. In: Lethal arrhythmias resulting from myocardial ischemia and infarction. Rosen MR, Palti Y, Kluwer Academic Publishers, Boston/Dordrecht/London. 1989:181–197.CrossRefGoogle Scholar
- 10.Gordon H, Sweets HH: Simple method for the silver impregnating of reticulum. Amer J Pathol 1936; 12:545–550.Google Scholar
- 11.Spach MS, Dolber PC, Heidlage JF: Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation. Circ Res 1988;62:811–832.PubMedCrossRefGoogle Scholar