Abstract
To demonstrate the mechanism of decrease in proteinuria after cyclosporine A (CYA) therapy, the ultrastructural alterations of glomerular anionic sites (AS) were studied in puromycin nehrotic rats using Polyethylenimine (PEI) as a cationic probe. CYA not only inhibited the increase in proteinuria induced by puromycin, but also recovered the decreased glomerular AS up to the control level. These results indicate that recovery of glomerular polyanion is a principal mecanism of decrease in proteinuria in CYA treatment.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Tejani, A., Butt, K., Trachtman, H., Suthanthiran, M., Rosenthal, C. J., Khawar, M. R. Kidney Int. 33: 729–734, 1988.
Meyrier, A., Simon, P., Perret, G., Meyrier, M-C. C. Br. Med. J. 292: 789–792, 1986.
Michael, A. F., Blau, E., Vernier, R. L. Lab. Invest. 23: 649–657, 1970.
Caulf ield, J. P., Farquhar, M. G. Lab. Invest. 39: 505–512, 1978.
Schurer, J. W., Kalicharan, D., Hoedemaeker, PH. J., Molenaar, I. J. Histchem. Cytochem. 26: 688–689, 1978.
Azuma, T., Tanabe, T. Unpublished data.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Azuma, T., Tanabe, T. (1991). Effect of Cyclosporine a on the Anionic Sites in the Glomerular Basement Membrane of Puromycin Nephrotic Rats. In: Andreucci, V.E., Dal Canton, A. (eds) New Therapeutic Strategies in Nephrology. Developments in Nephrology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3884-4_23
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3884-4_23
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6732-1
Online ISBN: 978-1-4615-3884-4
eBook Packages: Springer Book Archive