Modulation of Endothelial Barrier and Coagulant Properties by Hypoxia
Endothelial cells, which form the luminal vascular surface, regulate both barrier function, and pro- and anticoagulant reactions, by the controlling expression of cell surface molecules, such as receptors that regulate the hemostatic balance and those that affect permeability across the endothelial monolayer(1–3). This regulation occurs in response to environmental stimuli, such as hypoxia, which has a central role in the vascular injury due to ischemia. In this study, we have examined mechanisms that can lead to the perturbation of endothelial cell function in hypoxia, to gain insights into the pathogenesis of vascular dysfunction under hypoxia.
KeywordsBarrier Function Procoagulant Activity Endothelial Cell Function Endothelial Monolayer Endothelial Cell Surface
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