Modulation of Endothelial Barrier and Coagulant Properties by Hypoxia

  • S. Ogawa
  • M. Matsumoto
  • C. Esposito
  • D. Stern
Part of the Developments in Nephrology book series (DINE, volume 30)


Endothelial cells, which form the luminal vascular surface, regulate both barrier function, and pro- and anticoagulant reactions, by the controlling expression of cell surface molecules, such as receptors that regulate the hemostatic balance and those that affect permeability across the endothelial monolayer(1–3). This regulation occurs in response to environmental stimuli, such as hypoxia, which has a central role in the vascular injury due to ischemia. In this study, we have examined mechanisms that can lead to the perturbation of endothelial cell function in hypoxia, to gain insights into the pathogenesis of vascular dysfunction under hypoxia.


Barrier Function Procoagulant Activity Endothelial Cell Function Endothelial Monolayer Endothelial Cell Surface 
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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • S. Ogawa
    • 1
  • M. Matsumoto
    • 2
  • C. Esposito
    • 1
  • D. Stern
    • 1
  1. 1.Department of Physiology and Cellular BiophysicsCollege of Physicians and Surgeons, Columbia UniversityNew YorkUSA
  2. 2.1st Department of MedicineOsaka University Medical School HospitalOsakaJapan

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