Celiac axis infusion (CAI) chemotherapy for advanced gastric cancer

  • K. R. Aigner
  • F. Benthin
  • H. Müller
Part of the Cancer Treatment and Research book series (CTAR, volume 55)


Long-term prognosis of gastric cancer patients mainly depends on early diagnosis. Patients submitted to surgery in advanced stages III and IV do not have more than a 10% 5-year survival expectancy [4]. Although gastric cancer has been proved to be chemosensitive [2,3,5,7], and the rationale for adjuvant chemotherapy is therefore well established, there are no sufficient data so far to demonstrate any substantial benefit in survival. To date radical surgery for early gastric cancer remains the only therapeutic modality with a significant cure rate. It has been the objective of this pilot study to find out whether increased local drug concentrations, given via the arterial route through the celiac axis, lead to higher local response rates than systemic chemotherapy, and therefore potentially induce backstaging of the loco-regional tumor burden.


Gastric Cancer Gastric Cancer Patient Early Gastric Cancer Advanced Gastric Cancer Celiac Axis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Aigner K.R., Müller H, 1990. Intra-arterial chemotherapy with MMC, CDDP and 5-FU for nonresectable pancreatic cancer — a phase II study. Regional Cancer Treatment 3:1–6.Google Scholar
  2. 2.
    Douglass HO, 1985. Gastric cancer. Overview of current therapies. Semin Oncol 12(3, Suppl. 4):57–62.PubMedGoogle Scholar
  3. 3.
    Gohmann JJ, Macdonald JS, 1989. Chemotherapy of gastric cancer. Cancer Invest 7(1):39–52.PubMedCrossRefGoogle Scholar
  4. 4.
    Kelsen D, 1988. Chemotherapy of gastric cancer: A review. Israel J Med Sci 24:557–561.PubMedGoogle Scholar
  5. 5.
    Saji S, Kishimoto Y, Sakata K, Furuta T, Hiromi T, Kawata R, 1987. Advanced gastric cancer successfully resected following cisplatin therapy: Report of a case. J Surg Oncol 36:138–141.PubMedCrossRefGoogle Scholar
  6. 6.
    Stephens FO, 1988. Management of gastric cancer with regional chemotherapy preceding gastrectomy — 5-year survival results. Reg Cancer Treat 1:80–82.Google Scholar
  7. 7.
    Tanemura H, Kawata R, Suzuki M, Shimokawa K, Azuma S, Furuta T, Saji S, Ohashi H, Sakata K, 1988. Cure of advanced gastric cancer by combined chemotherapy with cisplatinum, mitomycin C and 5-fluorouracil. J Surgical Oncol 38:26–32.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • K. R. Aigner
  • F. Benthin
  • H. Müller

There are no affiliations available

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