Abstract
Long-term prognosis of gastric cancer patients mainly depends on early diagnosis. Patients submitted to surgery in advanced stages III and IV do not have more than a 10% 5-year survival expectancy [4]. Although gastric cancer has been proved to be chemosensitive [2,3,5,7], and the rationale for adjuvant chemotherapy is therefore well established, there are no sufficient data so far to demonstrate any substantial benefit in survival. To date radical surgery for early gastric cancer remains the only therapeutic modality with a significant cure rate. It has been the objective of this pilot study to find out whether increased local drug concentrations, given via the arterial route through the celiac axis, lead to higher local response rates than systemic chemotherapy, and therefore potentially induce backstaging of the loco-regional tumor burden.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aigner K.R., Müller H, 1990. Intra-arterial chemotherapy with MMC, CDDP and 5-FU for nonresectable pancreatic cancer — a phase II study. Regional Cancer Treatment 3:1–6.
Douglass HO, 1985. Gastric cancer. Overview of current therapies. Semin Oncol 12(3, Suppl. 4):57–62.
Gohmann JJ, Macdonald JS, 1989. Chemotherapy of gastric cancer. Cancer Invest 7(1):39–52.
Kelsen D, 1988. Chemotherapy of gastric cancer: A review. Israel J Med Sci 24:557–561.
Saji S, Kishimoto Y, Sakata K, Furuta T, Hiromi T, Kawata R, 1987. Advanced gastric cancer successfully resected following cisplatin therapy: Report of a case. J Surg Oncol 36:138–141.
Stephens FO, 1988. Management of gastric cancer with regional chemotherapy preceding gastrectomy — 5-year survival results. Reg Cancer Treat 1:80–82.
Tanemura H, Kawata R, Suzuki M, Shimokawa K, Azuma S, Furuta T, Saji S, Ohashi H, Sakata K, 1988. Cure of advanced gastric cancer by combined chemotherapy with cisplatinum, mitomycin C and 5-fluorouracil. J Surgical Oncol 38:26–32.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
Aigner, K.R., Benthin, F., Müller, H. (1991). Celiac axis infusion (CAI) chemotherapy for advanced gastric cancer. In: Sugarbaker, P.H. (eds) Management of Gastric Cancer. Cancer Treatment and Research, vol 55. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3882-0_20
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3882-0_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6731-4
Online ISBN: 978-1-4615-3882-0
eBook Packages: Springer Book Archive