Skip to main content
SpringerLink
Log in

Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-CIS-Retinoic Acid

  • Chapter
Book cover Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Part of the book series: Developments in Oncology ((DION,volume 67))

  • 76 Accesses

Abstract

Oxygen radicals are implicated in various stages of carcinogenesis and radical scavengers inhibit tumorigenesis in some models (1–4). However, many presumed radical scavengers exhibit radical generating activity under certain conditions. For example, vitamin C (L-(+)-ascorbic acid) is well known to act as an antioxidant and a prooxidant (5–10). Its antioxidant activity derives from its ability to reduce peroxyl radicals that propagate lipid peroxidation or to reduce the oxidized form (tocopheryl oxyl radical) of the naturally-occuring antioxidant vitamin E (6,7,11). Its prooxidant activity is a result of its ability to reduce metals (especially Fe+3-complexes) to forms that react with O2 to initiate lipid peroxidation (5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Troll, W., and Weisner, R. (1985) Annu. Rev. Pharmacol. Toxicol. 25, 509–528

    Article  PubMed  CAS  Google Scholar 

  2. Cerutti, P. (1985) Science 227, 375–381

    Article  PubMed  CAS  Google Scholar 

  3. Kensler, T.W., and Taffe, B.G. (1986) Adv. Free Rad. Biol. 2, 347–387

    Article  CAS  Google Scholar 

  4. Perchellet, J.-P., and Perchellet, E.M. (1988) ISI Atlas of Science: Pharmacology 325–333

    Google Scholar 

  5. Wills, E.D. (1966) Biochem. J. 99, 667–676

    PubMed  CAS  Google Scholar 

  6. Bendich, A., Machlin, L.J., Scandura, O., Burton, G.W., and Wayner, D.D.M. (1986) Adv. Free Rad. Biol. 2, 419–444

    Article  CAS  Google Scholar 

  7. Doba, T., Burton, G.W., and Ingold, K.U. (1985) Biochim. Biophys. Acta 835, 298–303

    Article  PubMed  CAS  Google Scholar 

  8. Niki, E., Kawakami, A., Yamamoto, Y., and Yamiya, Y. (1985) Bull. Chem. Soc. Jpn. 58, 1971–1975

    Article  CAS  Google Scholar 

  9. Sadrzadeh, S.M.H., and Eaton, J.W. (1988) J. Clin. Invest. 82, 1510–1515

    Article  PubMed  CAS  Google Scholar 

  10. Frei, B., Stocker, R., and Ames, B.N. (1988) Proc. Natl. Acad. Sci. USA 85, 9748–9752

    Article  PubMed  CAS  Google Scholar 

  11. Packer, J.E., Slater, T.F., and Willson, R.L. (1979) Nature 278, 737–738

    Article  PubMed  CAS  Google Scholar 

  12. Roberts, A.B., and Sporn, M.B. (1984) in The retinoids (Sporn, M.B., Roberts, A.B., and Goodman, D.S., eds) pp. 210-286, Academic Press, New York

    Google Scholar 

  13. Peck, G.L., Olsen, T.G., Yoder, F.W., Strauss, J.S., Downing, D.T., Pandya, M., Butkus, D., and Arnaud-Battandier, J. (1979) N. Engl. J. Med. 300, 329–333

    Article  PubMed  CAS  Google Scholar 

  14. Bollag, W. (1972) Eur. J. Cancer 8, 689–693

    Article  PubMed  CAS  Google Scholar 

  15. Verma, A.K., Rice, H.M., Shapas, B.G., and Boutwell, R.K. (1978) Cancer Res. 38, 793–801

    PubMed  CAS  Google Scholar 

  16. Verma, A.K., Shapas, B.G., Rice, H.M., and Boutwell, R.K. (1979) Cancer Res. 39, 419–425

    PubMed  CAS  Google Scholar 

  17. Weiss, J.S., Ellis, C.N., Headington, J.T., Tincoff, T., Hamilton, T.A., and Voorhees, J.J. (1988) J. Am. Med. Assn. 259, 527–532

    Article  CAS  Google Scholar 

  18. Frolik, C.A., Roller, P.P., Roberts, A.B., and Sporn, M.B. (1980) J. Biol. Chem. 255, 8057–8062

    PubMed  CAS  Google Scholar 

  19. Vane, F.M., Bugge, J.L., and Williams, T.H. (1982) Drug Metab. Dispos. 253, 7319–7324

    Google Scholar 

  20. McCormick, A.M., Napoli, J.L., Schnoes, H.K., and DeLuca, H.F. (1979) Arch. Biochem. Biophys. 192, 577–583

    Article  PubMed  CAS  Google Scholar 

  21. Sietsma, W.K., and DeLuca, H.F. (1982) J. Biol. Chem. 257, 4265–4270

    Google Scholar 

  22. Marnett, LJ. (1984) in Free Radicals in Biology, Vol 6 (Pryor, W.A., ed) pp. 63-94, Academic Press, New York

    Google Scholar 

  23. Eling, T.E., Thompson, D.C., Foureman, G.L., Curtis, J.F., and Hughes, M.F. (1990) Annu. Rev. Pharmacol. Toxicol. 30, 1–45

    Article  PubMed  CAS  Google Scholar 

  24. Markey, C.M., Alward, A., Weller, P.E., and Marnett, L.J. (1987) J. Biol. Chem. 262, 6266–6279

    PubMed  CAS  Google Scholar 

  25. Tunek, A., Platt, K.L., Bentley, P., and Oesch, F. (1978) Mol. Pharmacol. 14, 920–929

    PubMed  CAS  Google Scholar 

  26. Baumgartner, W.A., Baker, N., Hill, V.A., and Wright, E.T. (1975) Lipids 10, 309–311

    Article  PubMed  CAS  Google Scholar 

  27. Beuge, J.A., and Aust, S.D. (1978) Methods. Enzymol. 105, 302–311

    Article  Google Scholar 

  28. Bull, A.W., and Marnett, L.J. (1985) Anal. Biochem. 149, 284–290

    Article  PubMed  CAS  Google Scholar 

  29. Orrenius, S., Dallner, G., and Ernster, L. (1964) Biochem. Biophys. Res. Comm. 14, 329–334

    Article  PubMed  CAS  Google Scholar 

  30. Buege, J.A., and Aust, S.D. (1978) Methods. Enzymol. 52, 302–310

    Article  PubMed  CAS  Google Scholar 

  31. Hrycay, E., and O’Brien, P.J. (1971) Arch. Biochem. Biophys. 147, 14–27

    Article  PubMed  CAS  Google Scholar 

  32. Laudicina, D.C., and Marnett, L.J. (1990) Arch. Biochem. Biophys. 278, 73–80

    Article  PubMed  CAS  Google Scholar 

  33. Pryor, W.A. (1966) Free radicals, McGraw-Hill, New York

    Google Scholar 

  34. Samokyszyn, V.M., and Marnett, L.J. (1987) J. Biol. Chem. 262, 14119–14133

    PubMed  CAS  Google Scholar 

  35. Jungalwala, F.B., and Cama, H.R. (1965) Biochem. J. 95, 17–26

    PubMed  CAS  Google Scholar 

  36. O’Brien, P.J., and Rahimtula, A. (1975) J. Agr. Food Chem. 23, 154–158

    Article  Google Scholar 

  37. Masuda, Y., and Murano, T. (1978) Jap. J. Pharmacol. 29, 179–186

    Article  Google Scholar 

  38. Iba, M.M., and Mannering, G.J. (1987) Mol. Pharmacol. 36, 1447–1455

    CAS  Google Scholar 

  39. Minotti, G. (1988) Arch. Biochem. Biophys. 268, 398–403

    Article  Google Scholar 

  40. Egan, R.W., Paxton, J., and Kuehl, F.A. (1976) J. Biol. Chem. 251, 7329–7335

    PubMed  CAS  Google Scholar 

  41. Schewe, T., Albracht, S.P.J., and Ludwig, P. (1981) Biochim. Biophys. Acta 636, 210–217

    Article  PubMed  CAS  Google Scholar 

  42. Ingold, K. (1969) Acc. Chem. Res. 2, 1–9

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. A.B. Hancock, Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry and Chemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    L. J. Marnett, V. Samokyszyn & D. Laudicina

Authors
  1. L. J. Marnett
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Samokyszyn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Laudicina
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, Detroit, MI, USA

    Kenneth V. Honn

  2. Department of Biochemistry, Vanderbilt University, Nashville, TN, USA

    Lawrence J. Marnett

  3. Department of Gynecological Endocrinology Klinikum Steglitz, Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. Department of Radiation Biochemistry, Armed Forces Radiobiology Research Institute, Bethesda, MD, USA

    Thomas L. Walden Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Marnett, L.J., Samokyszyn, V., Laudicina, D. (1991). Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-CIS-Retinoic Acid. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-3874-5_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6727-7

  • Online ISBN: 978-1-4615-3874-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation