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Enhancement of Colonic Carcinogenesis by Dietary Fat: Role of Essential, Oxidized, Polyunsaturated and Saturated Fatty Acids

  • A. W. Bull
Chapter
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

The major factor affecting the development of intestinal carcinogenesis in both animals and man appears to be environmental in origin. Clearly, the major environmental factor affecting the colon is the diet and the most important tumor enhancing component of the diet appears to be the type and level of fat (1). There have been numerous studies investigating the relationship between the risk of colon tumor formation and the fat content of the diet. A majority, but certainly not all, studies in animals have suggested that animals consuming high levels of dietary fat develop more tumors than animals consuming lower levels of fat. More recently it has been shown that the particular fatty acid content of the dietary fat is often as important as the total amount of fat (2). The present paper will examine a few selected mechanisms by which dietary fat could enhance intestinal tumorigenesis.

Keywords

Bile Acid Fatly Acid Colonic Tumorigenesis Intestinal Tumorigenesis Intestinal Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Abraham, S. (ed.) Carcinogenesis and Dietary Fat Kluwer Academic Publishers, Norwell, MA 1989.Google Scholar
  2. 2.
    Reddy, B.S., and Maeura, Y. J. Nat’l Cancer Inst. USA 72: 745–750,1984.Google Scholar
  3. 3.
    Reddy, B.S., Weisburger, J.H., and Wynder, E.L. In: Carcinogenesis: A Comprehensive Survey,Vol. 2, (eds. Slaga, T.J., Sivak, A., and Boutwell, R.K.) Raven Press, New York, 1978, pp. 453–464.Google Scholar
  4. 4.
    Sakaguchi, M, Hiramatsu, R., Takada, H., Yamamura, M., Hioki, K., Saito, K., Yamamoto, M. Cancer Res. 44:1472–1477,1984.PubMedGoogle Scholar
  5. 5.
    Ip, C, Carter, C.A., and Ip, M.M. Cancer Res. 45:1997–2001,1985.PubMedGoogle Scholar
  6. 6.
    Bull, A.W., Bronstein, J.C., and Nigro, N.D. Lipids 24: 340–346,1989.PubMedCrossRefGoogle Scholar
  7. 7.
    Bull, A.W., Nigro, N.D., and Marnett, L.J. Cancer Res. 48:1771–1776,1988.PubMedGoogle Scholar
  8. 8.
    Dix, T.A., and Marnett, L.J. J. Biol. Chem. 260: 5351–5357,1985.PubMedGoogle Scholar
  9. 9.
    Gardner, H.W., Weisleder, D., and Nelson, E.C. J. Org. Chem. 49:508–515, 1984.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • A. W. Bull
    • 1
  1. 1.Department of ChemistryOakland UniversityRochesterUSA

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