Biochemistry of Oxidant Injury

  • I. U. Schraufstatter
  • J. H. Jackson
  • O. Quehenberger
  • C. G. Cochrane
Part of the Developments in Oncology book series (DION, volume 67)


Neutrophils attracted to an area of inflammation are stimulated to produce O2-, the degradation products of which (H2O2, -OH, HOCI, etc.) are potent bactericidal as well as cytotoxic agents. In order to determine the pathways of oxidative injury, target cells were exposed to various oxidizing agents. This report will only be concerned with the effect of H2O2. In order to simplify the determination of kinetics a single bolus of reagent H2O2 was used.


Phorbol Myristate Acetate Endonuclease Activation P388D1 Cell Dependent Endonuclease Thymine Glycol 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • I. U. Schraufstatter
    • 1
  • J. H. Jackson
    • 1
  • O. Quehenberger
    • 1
  • C. G. Cochrane
    • 1
  1. 1.Department of ImmunologyResearch Institute of Scripps ClinicLa JollaUSA

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