Chapter

Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Volume 67 of the series Developments in Oncology pp 189-197

Prostaglandins, Radiation, and Thermoregulation

  • S. B. KandasamyAffiliated withBehavioral Sciences Department, Armed Forces Radiobiology Research Institute
  • , W. A. HuntAffiliated withBehavioral Sciences Department, Armed Forces Radiobiology Research Institute

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Abstract

Changes in body temperature can be observed after radiation exposure (1), an effect that depends on the species being used. For example, radiation induces hyperthermia in cats, rabbits (2), and humans (3); a biphasic response in monkeys (a fall followed by a rise (4)); a dual effect in rats (low and high doses produce hyperthermia and hypothermia, respectively (5)); and hypothermia in guinea pigs (6). However, the mechanisms underlying hyperthermia and hypothermia due to radiation are unknown.