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Lipid Peroxidation in Late Radiation Injury of the Rat Spinal Cord

  • K. J. Levin
  • P. H. Gutin
  • M. W. Mcdermott
  • G. Y. Ross
  • N. Hooper
  • M. T. Smith
  • J. R. Cashman
  • P. M. Chan
  • R. L. Davis
  • T. L. Phillips
Chapter
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

Radiation therapy is a highly effective treatment for malignant gliomas and there is good evidence that increasing radiation dose results in increased survival (1,2). However, damage to the surrounding normal tissue limits the total dose of radiation which can be delivered (3). Because CNS tumors rarely metastasize, local control in these devastating conditions can translate into cure. It was thought that interstitial brachytherapy might alleviate the problem of therapeutic ratio, yet it has become quite clear that radiation necrosis is the limiting factor for this technique as well (4).

Keywords

Lipid Peroxidation Dose Response Curve Central Nervous System Tumor Radiation Injury Radiation Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • K. J. Levin
    • 1
  • P. H. Gutin
    • 1
  • M. W. Mcdermott
    • 1
  • G. Y. Ross
    • 1
  • N. Hooper
    • 1
  • M. T. Smith
    • 1
  • J. R. Cashman
    • 1
  • P. M. Chan
    • 1
  • R. L. Davis
    • 1
  • T. L. Phillips
    • 1
  1. 1.Departments of Radiation Oncology, Neurological Surgery, Pharmaceutical Chemistry, Neurology, and PathologyUniversity of California, San Francisco, and School of Public Health, University of CaliforniaBerkeleyUSA

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