8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents
Introduction and Summary
It has been suggested that oxygen radicals are involved in both initiation and promotion of carcinogenesis (1,2). Oxygen radicals are produced by mutagens/carcinogens in the environment, but are also formed during various kinds of cellular metabolism. We previously observed that the C-8 position of deoxyguanosine residues in DNA is hydroxylated to produce 8-hydroxydeoxyguanosine (8-OH-dG) in DNA in vitro by various oxygen radical-producing agents (3). The formation of 8-OH-dG was also observed in cellular DNA when mice or rats were irradiated by ionizing radiation or administrated oxygen radical-forming carcinogens (4–6).
KeywordsOxygen Radical Potassium Bromate Alkaline Phosphomonoesterase 12th Codon Human Peripheral Blood Leukocyte
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