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8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents

  • H. Kasai
  • M.-H. Chung
  • D. S. Jones
  • H. Inoue
  • H. Ishikawa
  • H. Kamiya
  • E. Ohtsuka
  • S. Nishimura
Chapter
Part of the Developments in Oncology book series (DION, volume 67)

Introduction and Summary

It has been suggested that oxygen radicals are involved in both initiation and promotion of carcinogenesis (1,2). Oxygen radicals are produced by mutagens/carcinogens in the environment, but are also formed during various kinds of cellular metabolism. We previously observed that the C-8 position of deoxyguanosine residues in DNA is hydroxylated to produce 8-hydroxydeoxyguanosine (8-OH-dG) in DNA in vitro by various oxygen radical-producing agents (3). The formation of 8-OH-dG was also observed in cellular DNA when mice or rats were irradiated by ionizing radiation or administrated oxygen radical-forming carcinogens (4–6).

Keywords

Oxygen Radical Potassium Bromate Alkaline Phosphomonoesterase 12th Codon Human Peripheral Blood Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • H. Kasai
    • 1
  • M.-H. Chung
    • 1
  • D. S. Jones
    • 1
  • H. Inoue
    • 2
  • H. Ishikawa
    • 2
  • H. Kamiya
    • 2
  • E. Ohtsuka
    • 2
  • S. Nishimura
    • 1
  1. 1.Biology DivisionNational Cancer Center Research InstituteChuo-ku, TokyoJapan
  2. 2.Faculty of Pharmaceutical SciencesHokkaido UniversitySapporoJapan

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