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Tumor Promotion and the Arachidonate Cascade

  • S. M. Fischer
  • G. S. Cameron
  • K. E. Patrick
  • J. Leyton
  • R. J. Morris
Chapter
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

Experimental chemical carcinogenesis studies in animals, particularly the multistage model in mouse skin (1-3) are valuable in identifying those biological events or agents that play either an essential or modulatory role in the development of tumors. The promotion stage is most often accomplished by using 12-O-tetradecanoyl phorbol-13-acetate (TPA), although a variety of agents have been identified as skin-tumor promoters (3,4). Among the many morphological and biochemical responses of the skin to promoters, the induction of inflammation followed by increased epidermal cell proliferation (hyperplasia) are events common to all promoters and appear to be required events (5).

Keywords

Arachidonic Acid Epidermal Cell Benzoyl Peroxide Tumor Promotion Arachidonic Acid Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • S. M. Fischer
    • 1
  • G. S. Cameron
    • 1
  • K. E. Patrick
    • 1
  • J. Leyton
    • 1
  • R. J. Morris
    • 1
  1. 1.University of Texas Cancer Center, Science ParkSmithvilleUSA

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