Tumor Promotion and the Arachidonate Cascade

  • S. M. Fischer
  • G. S. Cameron
  • K. E. Patrick
  • J. Leyton
  • R. J. Morris
Part of the Developments in Oncology book series (DION, volume 67)


Experimental chemical carcinogenesis studies in animals, particularly the multistage model in mouse skin (1-3) are valuable in identifying those biological events or agents that play either an essential or modulatory role in the development of tumors. The promotion stage is most often accomplished by using 12-O-tetradecanoyl phorbol-13-acetate (TPA), although a variety of agents have been identified as skin-tumor promoters (3,4). Among the many morphological and biochemical responses of the skin to promoters, the induction of inflammation followed by increased epidermal cell proliferation (hyperplasia) are events common to all promoters and appear to be required events (5).


Arachidonic Acid Epidermal Cell Benzoyl Peroxide Tumor Promotion Arachidonic Acid Release 
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  1. 1.
    Slaga, T.J., Fischer, S.M., Nelson, K., and Gleason, G.L. Proc. Natl. Acad. Sci., USA, 77:3659–3663, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Slaga, T.J., Fischer, S.M., Weeks, C.E., and Klein-Szanto, A.J.P. In: Rev. Biochem. Tox. (Elsevier/North Holland Publishing, NY.) pp. 231–282,1981.Google Scholar
  3. 3.
    Slaga, T.J. In: Mechanisms of Tumor Promotion (CRC Press, Boca Raton, FL) pp. 1–16,1984.Google Scholar
  4. 4.
    DiGiovanni, J., Decina, P.C., Pritchett, W.P., Canton, J., Aalfs, K.K., and Coombs, M.M. Cancer Res. 45:2584–2589, 1985.PubMedGoogle Scholar
  5. 5.
    Gschwendt, M., Kittstein, W, Furstenberger, G. and Marks, G. Cancer Lett. 25:177–185, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    Arachidonic Acid Metabolism and Tumor Promotion, eds. S.M. Fischer and T.J. Slaga, Martinus Nijhoff Publ., Boston, 1985.Google Scholar
  7. 7.
    Fischer, S.M., Gleason, G.L., Bohrman, J.S., and Slaga, T.J. Carcinogensis. 1:245–248, 1980.CrossRefGoogle Scholar
  8. 8.
    Fischer, S.M., Cameron, G.S., Baldwin, J.K., Jasheway, D.W., Patrick, K.E., and Belury, M.A. In: Skin Carcinogenesis: Mechanisms and Human Relevance, Alan R. Liss, Inc., N.Y. 1989, pp 249–264.Google Scholar
  9. 9.
    Leyton, J., Lee, M., Locniskar, M., Fischer, S. (in preparation).Google Scholar
  10. 10.
    Fischer, S.M., Baldwin, J.K., Jasheway, D.W., Patrick, K.E, Cameron, G.S. Cancer Res. 48: 658–664,1988.PubMedGoogle Scholar
  11. 11.
    Fischer, S.M., Nelson, KDG, Reiners, J.J. Jr., Viaje, A., Pelling, J.C., Slaga, T.J. J. Cutaneous Pathol. 9:43–49,1982.CrossRefGoogle Scholar
  12. 12.
    Nishizuka,Y. Science 233:305–312, 1986.PubMedCrossRefGoogle Scholar
  13. 13.
    Van Duuren, B.L., Tseng, S.S., Segal, A., Smith, A.C., Melchionne, S., Seidman, I. Cancer Res. 39:2644–2646, 1979.PubMedGoogle Scholar
  14. 14.
    Nishizuka, Y. Cancer, 63:1892–1903,1989.PubMedCrossRefGoogle Scholar
  15. 15.
    Klein-Szanto, A.J.P. and Slaga, T.J. J. Invest. Dermatol. 79:30–34,1982.CrossRefGoogle Scholar
  16. 1 6.
    Cameron, G.S., Patrick, K.E. and Fischer, S.M. (in preparation).Google Scholar
  17. 17.
    Argyris, T.S. In: Carcinogenesis. Vol. 7, Raven Press, N.Y., 1982, pp 43–48.Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • S. M. Fischer
    • 1
  • G. S. Cameron
    • 1
  • K. E. Patrick
    • 1
  • J. Leyton
    • 1
  • R. J. Morris
    • 1
  1. 1.University of Texas Cancer Center, Science ParkSmithvilleUSA

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