Advertisement

Immunobiochemical and Molecular Biological Studies on Arachidonate 12-Lipoxygenase of Porcine Leukocytes

  • S. Yamamoto
  • T. Yoshimoto
  • H. Suzuki
  • N. Ueda
  • K. Natsui
  • Y. Takahashi
  • T. Maruyama
  • A. Hiroshima
  • F. Shinjo
  • K. Il
  • N. Komatsu
  • K. Watanabe
  • K. Gerozissis
  • F. Dray
  • C. Yokoyama
  • T. Takai
  • T. Tanabe
Chapter
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

Arachidonate 12-lipoxygenase is a dioxygenase which incorporates one molecule of oxygen into arachidonic acid regiospecifically and stereospecifically, and produces 12S-hydroperoxy-5,8,10,14-eicosatetraenoic acid (Figure 1). Since the enzyme was found in platelets as the first mammalian lipoxygenase (1,2), the 12-lipoxygenase has been found in a variety of tissues of a number of animal species (3,4). In addition to 12-lipoxygenase, several more lipoxygenases have been found in mammalian tissues. It is well known that the leukotriene synthesis is initiated by 5-lipoxygenase and the biosynthesis of prostaglandin and thromboxane by cyclooxygenase. These compounds have specific biological activities which regulate the functions of various animal tissues, and their biological functions have been generalized for a variety of animal species and tissues. However, no bioactive compound with such a general function has so far been found in the 12-lipoxygenase pathway of arachidonate metabolism (5).

Keywords

Arachidonic Acid Broad Substrate Specificity Immunoaffinity Chromatography Eicosatetraenoic Acid Specific Biological Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hamberg, M. and Samuelsson, B. Proc. Natl. Acad. Sci. USA. 71:3400–3404, 1974.PubMedCrossRefGoogle Scholar
  2. 2.
    Nugteren, D.H. Biochim. Biophys. Acta. 380:299–307, 1975.PubMedCrossRefGoogle Scholar
  3. 3.
    Yamamoto, S. In: Prostaglandins and Related Substances (Eds. C. Pace-Asciak, and E. Granstrom), Elsevier, Amsterdam, 1983, pp. 171-202.Google Scholar
  4. 4.
    Yamamoto, S. Prostaglandins Leukotrienes and Essential Fatty Acids Review 35:219–229, 1989.CrossRefGoogle Scholar
  5. 5.
    Brash, A.R. Circulation 72:702–707, 1985.PubMedCrossRefGoogle Scholar
  6. 6.
    Goetzl, E.J., Woods, J.M., and Gorman, R.R. J. Clin. Invest. 59:179–183, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Nakao, J., Ooyama, T., Ito, H., Chang, W.-C. and Murota, S. Atherosclerosis 44:339–342, 1982.PubMedCrossRefGoogle Scholar
  8. 8.
    Piomelli, D., Volterra, A., Dale, N., Siegelbaum, S.A., Kandel, E.R., Schwartz, J.H. and Belardetti, F. Nature 328:38–43, 1987.PubMedCrossRefGoogle Scholar
  9. 9.
    Carlen, P.L., Gurevich, N., Wu, P.H., Su, W.-G., Corey, E.J. and PaceAsciak. C.R. Brain Res. 497:171–176, 1989.PubMedCrossRefGoogle Scholar
  10. 10.
    Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., Nelson, K.K., Diglio, C.A., Taylor, J.D. and Honn, K.V. Cancer Res. 49:1029–1037, 1989.PubMedGoogle Scholar
  11. 11.
    Yoshimoto, T., Miyamoto, Y., Ochi, K. and Yamamoto, S. Biochim. Biophys. Acta 713:638–646, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Shinjo, F,, Yoshimoto, T,, Yokoyama, C, Yamamoto, S., Izumi, S., Komatsu, N. and Watanabe, K. J. Biol. Chem. 261:3377–3381, 1986.PubMedGoogle Scholar
  13. 13.
    Yokoyama, C, Shinjo, F., Yoshimoto, T., Yamamoto, S., Oates, J.A. and Brash, A.R. J. Biol. Chem. 261:16714–16721, 1986.PubMedGoogle Scholar
  14. 14.
    Claeys, M., Kivits, G.A.A., Christ-Hazelhof, E. and Nugteren, D.H. Biochim. Biophys. Acta 837:3551,1985.Google Scholar
  15. 15.
    Walstra, P., Verhagen, J., Vermeer, M.A., Veldink, G.A. and Vliegenthart, J.F.G. Biochim. Biophys. Acta 921:312–319, 1987.PubMedCrossRefGoogle Scholar
  16. 16.
    Takahashi, Y., Ueda, N. and Yamamoto, S. Arch. Biochem. Biophys. 266: 613–621 1988.PubMedCrossRefGoogle Scholar
  17. Ueda, N., Hiroshima, A., Natsui, K,, Shinjo, F., Yoshimoto, T., Yamamoto, S,, li, K., Gerozissis, K. and Dray, F. J. Biol. Chem. in press.Google Scholar
  18. 18.
    Maruyama, T., Ueda, N., Yoshimoto, T., Yamamoto, S,, Komatsu, N. and Watanabe, K. J. Histochem. Cytochem. 37:1125–1131, 1989.CrossRefGoogle Scholar
  19. 19.
    Dixon, R.A.F., Jones, R.E., Diehl, R.E., Bennett, CD., Kargman, S. and Rouzer, C.A. Proc. Natl.Acad. Sci. USA 85:416–420, 1988.PubMedCrossRefGoogle Scholar
  20. 20.
    Sigal, E., Craik, C.S., Highland, E., Grunberger, D., Costello, L.L., Dixon, R.A.F, and Nadel, J.A.Biochem. Biophys. Res. Commun. 157: 457–464, 1988.PubMedCrossRefGoogle Scholar
  21. 21.
    Pilote, S., Vallerand, P. and Borgeat, P. Biochem. Biophys. Res. Commun. 104:867–873, 1982.PubMedCrossRefGoogle Scholar
  22. 22.
    Yoshimoto, T., Kusaka, M., Shinjo, F., Yamamoto, S. and Dray, F. Prostaglandins 28:279–285, 1984.PubMedCrossRefGoogle Scholar
  23. 23.
    Vanderhoek, J.Y., Kiesel, L., Naor, Z., Bailey, J.M. and Catt, K.J. Prostagiandin Leukotriene and Medicine 15:375–385, 1984.CrossRefGoogle Scholar
  24. 24.
    Gerozissis, K., Vulliez, B., Saavedra, J.M., Murphy, R.C. and Dray, F. Neuroendocrinology 40:272276,1985.CrossRefGoogle Scholar
  25. 25.
    Sakai, K., Fafeur, V., Vulliez-le Normand, B. and Dray, F. Prostaglandins 35:969–976, 1988.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • S. Yamamoto
    • 1
  • T. Yoshimoto
    • 1
  • H. Suzuki
    • 1
  • N. Ueda
    • 1
  • K. Natsui
    • 1
  • Y. Takahashi
    • 1
  • T. Maruyama
    • 1
  • A. Hiroshima
    • 1
  • F. Shinjo
    • 1
  • K. Il
    • 2
  • N. Komatsu
    • 3
  • K. Watanabe
    • 3
  • K. Gerozissis
    • 4
  • F. Dray
    • 4
  • C. Yokoyama
    • 5
  • T. Takai
    • 5
  • T. Tanabe
    • 5
  1. 1.Departments of BiochemistryTokushima University, School of MedicineKuramotocho, TokushimaJapan
  2. 2.Departments of PathologyTokushima University, School of MedicineKuramotocho, TokushimaJapan
  3. 3.Department of PathologyTokai University, School of MedicineIseharaJapan
  4. 4.Unite de Radioimmunologie AnalytiqueInstitut PasteurParisFrance
  5. 5.Department of PharmacologyNational Cardiovascular Center, Research InstituteSuita, OsakaJapan

Personalised recommendations