Polysaccharides: “Naturals” for Cosmetics ad Pharmaceuticals

  • George L. Brode


Certain polysaccharides and polysaccharide derivatives are “natural” products for use in cosmetic and therapeutic applications. Polysaccharides are ubiquitous in nature, found extensively in both plants and animals. Largely of carbohydrate structure, this class of polymers is essentially derived from sugar-type molecules by cyclodehydration/addition reactions. Polymer properties and the resulting formulations containing them depend on several key structural parameters, including: (1) molecular weight and molecular weight distribution; (2) conformation and stereochemistry in the monomeric and oligomeric repeat units; (3) type of functional group(s); (4) derivatization - both the type and distribution; (5) charge density and distribution in ionic polymers; (6) hydrophile/lipophile ratios and distribution patterns, etc. These factors are discussed with a view to capitalizing on those features important for cosmetic and therapeutic applications. Emphasis is placed on cellulose derivatives, chitin/chitosan, and hyaluronic acid.


Alginic Acid Hyaluronic Acid Methyl Cellulose Ethyl Cellulose Hydroxypropyl Cellulose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    R. L. Whistler and J. N. BeMiller, Eds., “Industrial Gums: Polysaccharides and Their Derivatives, 2nd Ed., Academic Press, New York, 1973.Google Scholar
  2. 2.
    R. L. Davidson, Ed., “Handbook of Water Soluble Gums and Resins,” McGraw-Hill, New York, 1980.Google Scholar
  3. 3.
    A. Hebeisch and J. T. Guthrie, “The Chemistry and Technology of Cellulosic Copolymers, Springer-Verlag, Boca Raton, 1981.CrossRefGoogle Scholar
  4. 4.
    MIT Sea Grant Program, “Biotechnology of Marine Polysaccharides, Mass. Institute of Technology, 1984.Google Scholar
  5. 5.
    P. A. Sandford, et al., Pure and Applied Chemistry, 56(7), 879–892 (1984). “Microbial Polysaccharides: New Products and Their Commercial Applications.”CrossRefGoogle Scholar
  6. 6.
    O. B. Wurzburg, “Modified Starches: Properties and Uses, CRC Press, Boca Raton, 1986.Google Scholar
  7. 7.
    L. Landoll, U.S. Patent 4,529,523 (to Hercules Inc.), July 16, 1985, “Hydrophobically Modified Polymers.”Google Scholar
  8. 8.
    G. L. Brode, R. L. Kreeger, E. D. Goddard, F. M. Merritt and D. B. Braun, U.S. Patent 4,663,159 (to Union Carbide Chemicals and Plastics Company Inc.), May 5, 1987, “Hydrophobe Substituted, Water-Soluble Cationic Polysaccharides.”Google Scholar
  9. 9.
    R. A. A. Muzzarelli, “Chitin, Pergamon Press, London, 1978.Google Scholar
  10. 10.
    Chitin and Chitosan, 4th International Conference, August 1988, Trondheim, Norway.Google Scholar
  11. 11.
    G. L. Brode, J. P. Stanley and E. M. Partain, U.S. Patent 4,579,942 (to Union Carbide Chemicals and Plastics Company Inc.), April 1, 1986, “Polysaccharides, Methods for Preparing Such Polysaccharides and Fluids Utilizing Such Polysaccharides.”Google Scholar
  12. 12.
    E. M. Partain and G. L. Brode, U.S. Patent 4,929,722 (to Union Carbide Chemical and Plastics Company Inc.), May 29, 1990, “Acid Decrystillization of Aminopolysaccharides and Derivatives Thereof.”Google Scholar
  13. 13.
    D. Duchene and D. Wouessidjewe, Pharmaceutical Technology, 14, pp. 26, 28, 32, 34, June 1990. “Physiochemical Characteristics and Pharmaceutical Uses of Cyclodextrin Derivatives, Part I.”Google Scholar
  14. 14.
    R. Y. Lochhead, “The History of Polymers in Hair Care (1940-Present),” in: Encyclopedia of Polymers and Thickeners for Cosmetics: Cosmetics and Toiletries, 103, 23–61, December, 1988.Google Scholar
  15. 15.
    J. M. McGinity, “Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, Drugs and the Pharmaceutical Sciences Monographs, Marcel Dekker, Inc., New York, 1989.Google Scholar
  16. 16.
    A. G. Nigalaye, P. Adusumilli and S. Bolton, Drug Development and Industrial Pharmacy, 16(3), 449–467 (1990). “Investigation of Prolonged Drug Release From Matrix Formulations of Chitosan,”CrossRefGoogle Scholar
  17. 17.
    D. S. Jackson, U.S. Patent 4,659,700 (to Johnson & Johnson Products, Inc.), April 21, 1987, “Chitosan-Glycerol-Water Gel.”Google Scholar
  18. 18.
    G. L. Brode and E. M. Partain, U.S. Patent 4,946,870 (to Union Carbide Chemicals and Plastics Company Inc.), August 7, 1990, “Delivery Systems for Pharmaceutical or Therapeutic Actives.”Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • George L. Brode
    • 1
  1. 1.Union Carbide Chemicals and Plastics Company Inc.Bound BrookUSA

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