Role of Cognitive Processes in Immuno-Modulation in Cancer Disease

  • Kurt S. Zänker
  • Ronald M. Kroczek
  • Irene Hubertz
  • Volker Hodapp


Paul Ehrlich in 1909 recognized that an intact immune system was a requisite for maintenance of host resistance against neoplasia (1). This concept, refined by Burnet (2), postulated that T-lymphocytes recognize and monitor antigenic changes accompanying malignant transformations. Although substantial amount of evidence supports immune surveillance, other data place its validity in doubt (3). However, there is a common opinion among tumor immunologists that antitumor reactivity of immune lymphocytes is dependent principally upon cytotoxic T cells that recognize tumor-associated antigens in conjunction with histocompatibility complex antigens in cell membranes of antigen-presenting cells (macrophages, dendritic cells).


Immune Parameter Psychological Response Peripheral Lymph Node Anger Control Antigenic Change 
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  1. 1.
    P. Ehrlich, Uber den jetzigen Stand der Karzinomforschung. Ned. Tijdschr. Geneesk 5:273–290 (1909).Google Scholar
  2. 2.
    F.M. Burnet, Concept of immunological surveillance. Prog. Exp. Tumor Res. 13:1–27 (1970).PubMedGoogle Scholar
  3. 3.
    S. Sell, Tumor immunity. In: “Immunology, Immunopathology and Immunity,” 4th ed., pp. 725–786. Elsevier, New York, 1987.Google Scholar
  4. 4.
    J. Watson, Lymphokines and the incubation of immune responses. Transplantation 31:313–317 (1981).PubMedGoogle Scholar
  5. 5.
    W.A. Blattner and R.N. Hoover, Cancer in the immonusupressed host. In: “Cancer: Principles and Practice of Oncology” (J.T. DeVita, Jr., S. Hellman, and S. Rosenberg, Eds.), 2nd ed., chapt. 53, pp. 1999–2006. J.B. Lippencott, Philadelphia, 1985.Google Scholar
  6. 6.
    Abstr. Commun. Neuropeptides and Immunopeptides: Messengers in a Neuroimmune axis. New York Academy of Sciences, New York, Oct. 2–4, 1989.Google Scholar
  7. 7.
    M. Ferlic, A. Goldman, and B.J. Kennedy, Group counseling in adult patients with advanced cancer. Cancer 43:760–766 (1979).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Gustafson and H. Whitman, Towards a balanced social environment on the oncology service. Social Psychiatry 13:147–151 (1978).CrossRefGoogle Scholar
  9. 9.
    D. Spiegel and J. Bloom, Group therapy and hypnosis reduce metastatic breast carcinoma pain. Psychosom. Med. 45:333–337 (1983).PubMedGoogle Scholar
  10. 10.
    R. Grossarth-Maticek, P. Schmidt, H. Vetter, and S. Arndt, Psychotherapy research in oncology. In: “Health Care and Human Behavior” (A. Steptoe and A. Mathews, Eds.), pp. 325–340. Academic Press, London, 1984.Google Scholar
  11. 11.
    R. Grossarth-Maticek, J. Bastiaans, and D. Kanazir, Psychosocial factors as strong predictors of mortality from cancer, ischaemic heart disease and stroke. The Yugoslavia prospective study. J. Psychosom. Res. 29:167–176 (1985).PubMedCrossRefGoogle Scholar
  12. 12.
    D. Spiegel, H.C. Kraemer, J.R. Bloom, and E. Gottheil, Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet ii:888–891 (1989).CrossRefGoogle Scholar
  13. 13.
    Letters to the Editor: Psychological support for cancer patients. Lancet ii:1209–1210 (1989).Google Scholar
  14. 14.
    K.S. Zanker and R.M. Kroczek, Immunophenotyping, immunointervention and depression in cancer patients. A follow-up study in five bereaved patients. Int. J. Immunother. 4:235–241 (1988).Google Scholar

Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Kurt S. Zänker
    • 1
  • Ronald M. Kroczek
    • 1
  • Irene Hubertz
    • 2
  • Volker Hodapp
    • 2
  1. 1.Institute of ImmunologyUniversity Witten/HerdeckeWittenGermany
  2. 2.Institute of Physiological PsychologyHeinrich Heine UniversityDusseldorfGermany

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