Abstract
Paul Ehrlich in 1909 recognized that an intact immune system was a requisite for maintenance of host resistance against neoplasia (1). This concept, refined by Burnet (2), postulated that T-lymphocytes recognize and monitor antigenic changes accompanying malignant transformations. Although substantial amount of evidence supports immune surveillance, other data place its validity in doubt (3). However, there is a common opinion among tumor immunologists that antitumor reactivity of immune lymphocytes is dependent principally upon cytotoxic T cells that recognize tumor-associated antigens in conjunction with histocompatibility complex antigens in cell membranes of antigen-presenting cells (macrophages, dendritic cells).
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Zänker, K.S., Kroczek, R.M., Hubertz, I., Hodapp, V. (1991). Role of Cognitive Processes in Immuno-Modulation in Cancer Disease. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_59
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_59
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