Antimutagenic and Anticarcinogenic Mechanisms of Aminothiols

  • Silvio De Flora
  • Anna Camoirano
  • Alberto Izzotti
  • Patrizia Zanacchi
  • Maria Bagnasco
  • Carmelo F. Cesarone


Glutathione (GSH) and synthetic aminothiols, such as N-acetylcysteine (NAC), play an important role as inhibitors of mutagenesis and carcinogenesis (1). The present paper will update the studies carried out in our laboratories, which will be discussed according to a mechanistic approach. In Table 1, reporting the classification of inhibitors of mutagenesis and carcinogenesis proposed by De Flora and Ramel (2), the arrows indicate the mechanisms that we have investigated so far in the case of aminothiols.


Buthionine Sulfoximine Diethyl Maleate Pulmonary Alveolar Macrophage GSSG Reductase Nitrosation Reaction 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Silvio De Flora
    • 1
  • Anna Camoirano
    • 1
  • Alberto Izzotti
    • 1
  • Patrizia Zanacchi
    • 1
  • Maria Bagnasco
    • 1
  • Carmelo F. Cesarone
    • 1
    • 2
  1. 1.Institute of Hygiene and Preventive MedicineUniversity of GenoaGenoaItaly
  2. 2.Institute of General PhysiologyUniversity of GenoaGenoaItaly

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