Abstract
It has been known for about 30 years that the inactivation of biologically active macromolecules irradiated in vitro with X or gamma rays exhibit the dose-response phenomenon illustrated in Fig. 1. As shown in the figure, in pure buffer (control) the inactivation proceeds more or less at the same rate in the absence or in the presence of oxygen, as is very frequently observed with biological macromolecules such as DNA and enzymes (1). When a thiol is added to the solution, a marked oxygen effect becomes apparent.
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References
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M. Tamba, G. Simone, and M. Quintaliani (manuscript in preparation).
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Simone, G., Tamba, M., Quintiliani, M. (1991). Oxygen and Radical Scavengers in Radiation-Inactivation of Trypsin in Vitro . In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_35
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_35
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