Abstract
Specific anti-tumor cytotoxic lymphocytes (CTL) are one of the effectors of cell-mediated responses, which are considered to be important for the control of tumor rejection (1 – 3). However, the factors which regulate tumor-specific CTL proliferation and differentiation have not yet been completely defined.
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C.D. Mills and R.J. North, Expression of passivley transferred immunity against an established tumor depends on generation of cytolytic T cells in recipient. J. Exp. Med. 157:1448–1460 (1983).
T.K. Brunner, H.R. MacDonald, and J.C. Cerottini, Quantization and clonal isolation of cytolytic T lymphocyte precursors selectively infiltrating murine sarcoma virus-induced tumors. J. Exp. Med. 154: 362–373 (1981).
J.P. Klarnet, L.A. Matis, D.E. Kern, M.T. Mizuno, D.J. Peace, J.A. Thompson, P.D. Greenberg, and M.A. Cheever, Antigen-driven T cell clones can proliferate in vivo, eradicate disseminated leukemia, and provide specific immunological memory. J. Immunol. 138:4012–4017 (1987).
J.J. Farar, W.R. Benjamin, M.L. Hilfiker, M. Howard, W.L. Farar, and J. Fuller-Farar, The biochemistry, biology, and role of interleukin 2 in the induction of cytotoxic T cell and antibody-forming B cell responses. Immumol. Rev. 63:129–166 (1982).
F. Erard, P. Corthesy, M. Nabholz, J.W. Lowenthal, P. Zaech, G. Plaetinck, and H.R. MacDonald, Interleukin 2 is both necessary and sufficient for the growth and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J. Immunol. 134:1644–1650 (1985).
R.J. Robb, Interleukin 2: the molecule and its function, Immunol. Today 5:203–209 (1984).
F. Lee, T. Yokota, T. Otsuka, P. Meyerson, D. Villaret, R. Coffman, T. Mossman, D. Rennick, N. Roehm, C. Smith, A. Zlotnik, and K. Arai, Isolation and characterization of a mouse interluekin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell and mast-cell stimulating activities. Proc. Natl. Acad. Sci. USA. 83:2061–2065 (1986).
M.B. Widmer and K.H. Grabstein, Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor. Nature 326:795–800 (1987).
M.B. Widmer, R.B. Acres, H.M. Sassenfeld, and K.H. Grabstein, Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interluekin 4). J. Exp. Med 166:1447–1455 (1987).
J.D. Pfeifer, D.T. McKenzie, S.S. Swain and R.W. Dutton, B cell stimulatory factor 1 (interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors. J. Exp. Med. 166:1464–1470 (1987).
M.L. Kripke, Latency, histology, and antigenicity of tumors induced by ultraviolet light in three inbred mouse strains. Cancer Res. 37: 1395–1400 (1977).
M.S. Fisher and M.L. Kripke, Systematic alteration induced by ultraviolet light irradiation and its relationship to ultraviolet carcinogenesis. Proc. Natl. Acad. Sci. USA. 74:1688–1692 (1977).
P.M. Flood, M.L. Kripke, D.A. Rowley, and H. Schreiber, Suppression of tumor rejection by autologous anti-Idiotypic immunity. Proc. Natl. Acad. Sci. USA. 77:2209–2213 (1980).
B. Horvat and P.M. Flood, Tumor-specific cytotoxicity is mediated by both IL-2 and IL-4. Period. Biolog. (in press).
P.M. Flood, J.L. Urban, M.L. Kripke, and H. Schreiber, Loss of tumor-specific immunity with age. J. Exp. Med. 154:275–290 (1981).
J. Hu-Li, E.M. Shevach, J. Mizuguchi, J. Ohara, T. Mosmann, and W.E. Paul, B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes. J. Exp. Med. 165: 157–172 (1987).
K.H. Grabstein, L.S. Park, P.J. Morrisey, H. Sassenfeld. V. Price, D.L. Urdal, and M.B. Widmer, Regulation of T cell proliferation by B cell stimulatory factor 1. J. Immunol. 139:1148–1153 (1987).
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Horvat, B., Flood, P.M. (1991). Cellular and Molecular Analysis of Immune Response to Tumor Cells: Demand for IL-2 and IL-4 in the Generation of Specific Anti-Tumor Cytotoxicity. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_26
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DOI: https://doi.org/10.1007/978-1-4615-3850-9_26
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