Formation of 8-Hydroxydeoxyguanosine in DNA and Carcinogenesis

  • Hiroshi Kasai
  • Myung-Hee Chung
  • Haruo Kiyosawa
  • Eiko Ohtsuka
  • Susumu Nishimura

Abstract

Oxygen radicals are produced by ionizing radiation and many other environmental carcinogens. They are also produced endogenously in cells by oxygen metabolism. It seems important therefore to study DNA damage by oxygen radicals and its relation to carcinogenesis.

Keywords

Peroxide Hydroxyl Carbohydrate Glycol Adduct 

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Hiroshi Kasai
    • 1
  • Myung-Hee Chung
    • 1
  • Haruo Kiyosawa
    • 1
  • Eiko Ohtsuka
    • 2
  • Susumu Nishimura
    • 1
  1. 1.Biology DivisionNational Cancer Center Research InstituteTokyo 104Japan
  2. 2.Faculty of Pharmaceutical SciencesHokkaido UniversitySapporo 060Japan

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