Abstract
Mutagenic effects may arise from direct interaction of chemical and physical agents with DNA, from errors which occur during self-replication, from interference with nuclear division and from perturbations in DNA precursor pools (1). Cytosolic thymidine kinase (TK), a pyrimidine nucleotide salvage pathway enzyme closely associated with DNA synthesis has been found in Friend mouse leukemia (FEL) cells to influence sensitivity to mutagenic agents.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D. Anderson, C.R. Richardson and P.J. Davies, The genotoxic potential of bases and nucleosides. Mutat. Res. 91, 265–272 (1981).
P.G. McKenna and I. Hickey, UV sensitivity in thymidine kinase-deficient mouse erythroleukaemia cells. Cell Biol. Int. Rep. 5, 555–561 (1981).
P.G. McKenna and A.A. Yasseen, Increased sensitivity to cell killing and mutagenesis by chemical mutagens in thymidine kinase-deficient subclones of a Friend murine leukaemia cell line. Genet. Res. 40, 207–212 (1982).
P.G. McKenna, V.J. McKelvey and T.L. Frew, Sensitivity to cell killing and the induction of cytogenetic damage following gamma irradiation in wild-type and thymidine kinase-deficient Friend mouse erythroleukaemia cells. Mutat. Res. 200, 231–242 (1988).
V.J. McKelvey and P.G. McKenna, UV-induced cytogenetic damage in wild-type and thymidine kinase deficient Friend erythroleukaemia cells. Environ. Mol. Mutagen. 14 (SuDVl. 15), 127 (1989).
P.G. McKenna and A.A. Yasseen, Hypersensitivity of thymidine kinase-deficient Friend leukaemia cells to the induction of cytogenetic aberrations by mitomycin C. Leukemia Res. 9, 501–506 (1985).
V.J. McKelvey and P.G. McKenna, Enhanced synergism between caffeine and mitomycin C in the induction of cytogenetic aberrations in thymidine kinase-deficient Friend murine erythroleukaemia cells. Mutagenesis 1, 173–178 (1986).
P.G. McKenna, A.A. Yasseen and V.J. McKelvey, Evidence for indirect involvement of thymidine kinase in excision repair processes in mouse cell lines. Somatic Cell Mol. Genet. 11, 239–246 (1985).
P.G. McKenna and V.J. McKelvey, Abilities of wild-type and thymidine kinase-deficient Friend mouse erythroleukaemia cells to undergo unscheduled DNA synthesis following mutagen treatment. Somatic Cell Mol. Genet. 12, 325–332 (1986).
N.C. Brown and P. Reichard, Role of effector binding in allosteric control of ribonucleoside diphosphate reductase. J. Mol. Biol. 46, 39–55 (1969).
W. Scher, J.G. Holland and C. Friend, Haemoglobin synthesis in murine virus-induced leukaemia cells in vitro. Blood 37, 428–437 (1971).
P.G. McKenna and I. Hickey, The thymidine kinase locus of Friend erythroleukaemia cells. 1. Mutation rates and properties of mutants. Mutat. Res. 80, 187–199 (1981).
R.D. Snyder, Deoxyribonucleoside triphosphate pools in human diploid fibroblasts and their modulation by hydroxyurea and deoxynucleosides. Biochem. Pharmacol. 33, 1515–1518 (1984).
D. Hunting and J.F. Henderson, Methods for the determination of deoxynucleoside triphosphate concentrations. Methods Cancer Res. 20, 245–284 (1982).
Y.A. Wilkinson and P.G. McKenna, The effects of thymidine on deoxyribonucleotide pool levels cytotoxicity and mutation induction in Friend erythroleukaemia cells. Leukemia Res. 13, 615–620 (1989).
V.J. McKelvey and P.G. McKenna, Synergism between UV and thymidine treatments in the induction of cytogenetic damage in wild-type Friend erythroleukaemia cells. Leukemia Res. 12, 167–171 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media New York
About this chapter
Cite this chapter
McKenna, P.G., Wilkinson, Y.A., McKelvey, V.J. (1991). The Significance of Thymidine Kinase in Determining Resistance to Mutagenesis in Friend Mouse Leukemia Cells. In: Nygaard, O.F., Upton, A.C. (eds) Anticarcinogenesis and Radiation Protection 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3850-9_10
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3850-9_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6718-5
Online ISBN: 978-1-4615-3850-9
eBook Packages: Springer Book Archive