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Immunology of Milk and the Neonate pp 317–327Cite as

Passive Immune Protection from Diarrhea Caused by Rotavirus or E. Coli: An Animal Model to Demonstrate and Quantitate Efficacy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 310))

Abstract

Several studies have described the use of orally administered passive antibodies from heterologous species origin to control enteric disease caused by bacteria1–4, viruses5–13, and protozoa14. Both the therapeutic and prophylactic properties of passive antibodies have been evaluated. The therapeutic efficacy has been confined to suppressed pathogen shedding with limited effects reported on the acute clinical disease2,12. The reported lack of therapeutic effect on the course of the Escherichia coli and rotavirus diarrhea episodes may be attributed to the self-limiting nature of these diarrheas in healthy patients. Passive antibody is effective in treating Cryptosporidium infection14 and may also be effective in treating chronic diarrhea in immunocompromised patients.

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Authors and Affiliations

  1. Ross Laboratories, Columbus, OH, USA

    Christopher T. Cordle, Joseph P. Schaller, Timothy R. Winship, Edrick L. Candler, Milo D. Hilty, K. Larry Smith, Linda J. Saif, Erwin M. Kohler & Steven Krakowka

  2. The Ohio Agricultural Research and Development Center, Wooster, OH, USA

    Christopher T. Cordle, Joseph P. Schaller, Timothy R. Winship, Edrick L. Candler, Milo D. Hilty, K. Larry Smith, Linda J. Saif, Erwin M. Kohler & Steven Krakowka

  3. The Ohio State University, Columbus, OH, USA

    Christopher T. Cordle, Joseph P. Schaller, Timothy R. Winship, Edrick L. Candler, Milo D. Hilty, K. Larry Smith, Linda J. Saif, Erwin M. Kohler & Steven Krakowka

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  1. Christopher T. Cordle
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  2. Joseph P. Schaller
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  3. Timothy R. Winship
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  4. Edrick L. Candler
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  5. Milo D. Hilty
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  6. K. Larry Smith
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  7. Linda J. Saif
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  8. Erwin M. Kohler
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  9. Steven Krakowka
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Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky

  2. National Institutes of Health, Bethesda, Maryland, USA

    Claudia Blair

  3. University of Texas, Galveston, Texas, USA

    Pearay L. Ogra

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© 1991 Springer Science+Business Media New York

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Cordle, C.T. et al. (1991). Passive Immune Protection from Diarrhea Caused by Rotavirus or E. Coli: An Animal Model to Demonstrate and Quantitate Efficacy. In: Mestecky, J., Blair, C., Ogra, P.L. (eds) Immunology of Milk and the Neonate. Advances in Experimental Medicine and Biology, vol 310. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3838-7_41

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  • DOI: https://doi.org/10.1007/978-1-4615-3838-7_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6713-0

  • Online ISBN: 978-1-4615-3838-7

  • eBook Packages: Springer Book Archive

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