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Recent Advances in Development of a Rotavirus Vaccine for Prevention of Severe Diarrheal Illness of Infants and Young Children

  • Albert Z. Kapikian
  • Jorge Flores
  • Timo Vesikari
  • Tarja Ruuska
  • H. Paul Madore
  • Kim Y. Green
  • Mario Gorziglia
  • Yasutaka Hoshino
  • Robert M. Chanock
  • Karen Midthun
  • Irene Perez-Schael
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 310)

Abstract

Diarrheal diseases are an important cause of morbidity in infants and young children in developed countries and a major cause of both morbidity and mortality in this same age group in developing countriesl. The toll from diarrheal diseases in the developing countries is enormous. For example, it is estimated that in Asia, Africa, and Latin America, 3–5 billion cases of diarrhea and 5–10 million diarrhea-associated deaths occur each year2. In addition, diarrhea was ranked first among infectious diseases with regard to the number of episodes and the number of deaths in these areas of the world.

Keywords

Plaque Form Unit Quadrivalent Vaccine Oral Rehydration Salt Solution Heterotypic Protection JENNERIAN Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Albert Z. Kapikian
    • 1
  • Jorge Flores
    • 1
  • Timo Vesikari
    • 2
  • Tarja Ruuska
    • 2
  • H. Paul Madore
    • 3
  • Kim Y. Green
    • 1
  • Mario Gorziglia
    • 1
  • Yasutaka Hoshino
    • 1
  • Robert M. Chanock
    • 1
  • Karen Midthun
    • 4
  • Irene Perez-Schael
    • 5
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.University of TampereTampereFinland
  3. 3.University of RochesterRochesterUSA
  4. 4.Johns Hopkins UniversityBaltimoreUSA
  5. 5.Central University of VenezuelaCaracasVenezuela

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