Triazenes pp 185-193 | Cite as

Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives

  • E. S. Newlands
  • G. R. P. Blackledge
  • J. Slack
  • N. S. A. Stuart
  • M. F. G. Stevens


A series of imidazotetrazine derivatives were synthesised by Stevens and colleagues in the late 70′s (1). The activity of one of these derivatives, mitozolamide (8-carbamoyl-3-(2-chloroethyl)imidazo[5-1-d]-1,2,3,5-tetrazin-4(3H)-one) was identified and the compound’s ability to cross link DNA confirmed (2, 3, 4).


Anti Tumour Activity Small Cell Carcinoma Murine System P388 Leukaemia Charing Cross Hospital 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • E. S. Newlands
    • 1
  • G. R. P. Blackledge
    • 2
  • J. Slack
    • 3
  • N. S. A. Stuart
    • 2
  • M. F. G. Stevens
    • 3
  1. 1.Dept. of Medical OncologyCharing Cross HospitalLondonUK
  2. 2.Dept. of MedicineQueen Elizabth HospitalBirminghamUK
  3. 3.Dept. of Pharmaceutical SciencesAston UniversityBirminghamUK

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