Structure-Activity Correlations for the Ferric Uptake Regulation (FUR) Repressor Protein of Escherichia Coli K12
The purpose of this chapter will be to give an overview of certain features of microbial iron metabolism and to record what is known at the moment of writing regarding the molecular mechanism of regulation of high affinity iron absorption in Escherichia coli K-12. Evidence obtained by chemical modification experiments suggests that thiol groups may play a role in the activity of a protein (Fur) regulating iron absorption in this bacterial species.
KeywordsCysteine Assimilation Disulfide Thiol Histidine
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