Structure-Activity Correlations for the Ferric Uptake Regulation (FUR) Repressor Protein of Escherichia Coli K12

  • Stephen del Cardayre
  • J. B. Neilands


The purpose of this chapter will be to give an overview of certain features of microbial iron metabolism and to record what is known at the moment of writing regarding the molecular mechanism of regulation of high affinity iron absorption in Escherichia coli K-12. Evidence obtained by chemical modification experiments suggests that thiol groups may play a role in the activity of a protein (Fur) regulating iron absorption in this bacterial species.


Ferric Uptake Regulation Aerobacter Aerogenes Operator Fragment Regulate Iron Absorption Ferric Uptake Regulation Protein 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Stephen del Cardayre
    • 1
  • J. B. Neilands
    • 1
  1. 1.Biochemistry DepartmentUniversity of CaliforniaBerkeleyUSA

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