Aneuploidy in Humans
Aneuploidy, the change in chromosome number by the addition (trisomy) or loss (monosomy) of a single chromosome, has a most dramatic effect on the cells and organisms in which it occurs. It is extremely harmful because it changes the gene dosages and creates genetic imbalances of a large number of genes simultaneously.
KeywordsRecombination Dementia Fibril Infertility Colchicine
Unable to display preview. Download preview PDF.
- Barrett, J.C., Oshimura, M., Tanaka, N., and Tsutsui, T., 1985, Role of aneuploidy in early and late stages of neoplastic progression of Syrian Hamster embryo cells in culture, in: “Aneuploidy, Etiology and Mechanisms”, V.L. Dellarco, P.E. Voytek and A. Hollaender, eds., Plenum Press, N.Y.Google Scholar
- Bond, D.J., and Chandley, A.C., 1983, Aneuploidy, Oxford University Press.Google Scholar
- Devilee, P., Cremer, T., Slagboom, P., Bakker, E., Scholl, H.P., Hager, H.D., Stevenson, A.F.G., Cornelisse, C.J., and Pearson, P.L., 1986, Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13,18 and 21, Cytogenet. Cell Genet., 41:193.PubMedCrossRefGoogle Scholar
- Ford, J.H., and Russell, J.A, 1985, Differences in the error mechanisms affecting sex and autosomal chromosomes in women of different ages within the reproductive age group, Am. J. Human Genet., 37:973.Google Scholar
- Hamerton, J.L., Taylor, A.I., Angell, R., and McGuire, V.M., 1965, Chromosome investigations of a small isolated human population: Chromosome abnormalities and distribution of chromosome counts according to age and sex among the population of Tristan da Cunha, Nature, 206:1232.PubMedCrossRefGoogle Scholar
- Hassold, T.J., 1985, The origin of aneuploidy in humans, in: “Aneuploidy, Etiology and Mechanisms”, V.L. Dellarco, P.E. Voytek and A. Hollaender, eds., Plenum Press, N.Y.Google Scholar
- Hulten, M.A., Laurie, D.A., Martin, R.H., Saadallah, N., and Wallace, B.M.N., 1984, New techniques for detecting chromosome abnormalities in the germ-line in man, in: “Individual Susceptibility to Genotoxic Agents in the Human Population”, F.J. de Serres and R.W. Pero, eds., Plenum Press, N.Y.Google Scholar
- Hulten, M., Saadallah, N., Wallace, B.M.N., and Cockburn, D.J., 1985, Meiotic investigations of aneuploidy in the human, in: “Aneuploidy, Etiology and Mechanisms”, V.L. Dellarco, P.E. Voytek and A. Hollaender, eds., Plenum Press, N.Y.Google Scholar
- Saadallah, N., 1984, “Cytogenetic aspects of human male meiosis”, Ph.D. Thesis, The University of Birmingham.Google Scholar
- Stewart, G.D., Hassold, T.J., Berg, A., Watkins, P., Tanzi, R., and Kurnit, D.M., 1988, Trisomy 21 (Down syndrome)): Studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21, Am. J. Human Genet., 42:227.Google Scholar
- Sung, W.K., Komatsu, M., and Jagiello, G. (1983), A method for obtaining synaptonemal complexes of human pachytene oocytes, Caryologia 36:315.Google Scholar
- Zenzes, M.T., de Geyter, C., Bordt, J., Schneider, H.P.G., and Nieschlag, E., 1987, Cytological investigations of human eggs with unsuccessful fertilization, Am. J. Hum. Genet., 41:858.Google Scholar