Aneuploidy, the change in chromosome number by the addition (trisomy) or loss (monosomy) of a single chromosome, has a most dramatic effect on the cells and organisms in which it occurs. It is extremely harmful because it changes the gene dosages and creates genetic imbalances of a large number of genes simultaneously.


Down Syndrome Sister Chromatid Synaptonemal Complex Spindle Pole Aneuploid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barrett, J.C., Oshimura, M., Tanaka, N., and Tsutsui, T., 1985, Role of aneuploidy in early and late stages of neoplastic progression of Syrian Hamster embryo cells in culture, in: “Aneuploidy, Etiology and Mechanisms”, V.L. Dellarco, P.E. Voytek and A. Hollaender, eds., Plenum Press, N.Y.Google Scholar
  2. Bettner, L.G., and Jarvik, L.F., 1971, Stroop color-word test, non-psychotic organic brain syndrome and chromosome loss in aged twins, J. Gerontol., 26:458.PubMedCrossRefGoogle Scholar
  3. Bond, D.J., and Chandley, A.C., 1983, Aneuploidy, Oxford University Press.Google Scholar
  4. Choo, K.H., Brown, R., Webb, G., Craig, I.W., and Filby, R.G., 1987, Genomic organization of human centromeric alpha satellite DNA: Characterization of a chromosome 17 alpha satellite sequence, DNA, 6:277.CrossRefGoogle Scholar
  5. Devilee, P., Cremer, T., Slagboom, P., Bakker, E., Scholl, H.P., Hager, H.D., Stevenson, A.F.G., Cornelisse, C.J., and Pearson, P.L., 1986, Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13,18 and 21, Cytogenet. Cell Genet., 41:193.PubMedCrossRefGoogle Scholar
  6. Ford, J.H., and Congedi, M.M., 1987, Rapid induction of anaphase in competent cells by hypotonic treatment, Cytobios, 51:183.PubMedGoogle Scholar
  7. Ford, J.H., and Russell, J.A, 1985, Differences in the error mechanisms affecting sex and autosomal chromosomes in women of different ages within the reproductive age group, Am. J. Human Genet., 37:973.Google Scholar
  8. Ford, J.H., Schultz, C.J., and Correll, A.T., 1988, Chromosome elimination in micronuclei: A common cause of hypoploidy, Am. J. Hum. Genet., 43:733.PubMedGoogle Scholar
  9. Galt, J., Boyd, E., Connor, J.M., and Ferguson-Smith, M.A., 1989, Isolation of chromosome-21-specific DNA probes and their use in the analysis of nondisjunction in Down syndrome, Hum. Genet., 81:113.PubMedCrossRefGoogle Scholar
  10. Hamerton, J.L., Taylor, A.I., Angell, R., and McGuire, V.M., 1965, Chromosome investigations of a small isolated human population: Chromosome abnormalities and distribution of chromosome counts according to age and sex among the population of Tristan da Cunha, Nature, 206:1232.PubMedCrossRefGoogle Scholar
  11. Harnden, D.G., and O’Riordan, M.L., 1973, Down’s syndrome and leukaemia, Lancet, 1:260.PubMedCrossRefGoogle Scholar
  12. Hassold, T.J., 1985, The origin of aneuploidy in humans, in: “Aneuploidy, Etiology and Mechanisms”, V.L. Dellarco, P.E. Voytek and A. Hollaender, eds., Plenum Press, N.Y.Google Scholar
  13. Hassold, T., and Chiu, D., 1985, Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy, Hum. Genet., 70:11.PubMedCrossRefGoogle Scholar
  14. Hulten, M.A., Laurie, D.A., Martin, R.H., Saadallah, N., and Wallace, B.M.N., 1984, New techniques for detecting chromosome abnormalities in the germ-line in man, in: “Individual Susceptibility to Genotoxic Agents in the Human Population”, F.J. de Serres and R.W. Pero, eds., Plenum Press, N.Y.Google Scholar
  15. Hulten, M., Saadallah, N., Wallace, B.M.N., and Cockburn, D.J., 1985, Meiotic investigations of aneuploidy in the human, in: “Aneuploidy, Etiology and Mechanisms”, V.L. Dellarco, P.E. Voytek and A. Hollaender, eds., Plenum Press, N.Y.Google Scholar
  16. Jacobs, P.A., and Court Brown, W.M., (1966), Age and chromosomes, Nature, 212:823.PubMedCrossRefGoogle Scholar
  17. Martin, R.H., Rademaker, A.W., Hildebrand, K., Long-Simpson, L., Peterson, D., and Yamamoto, J., 1987, Hum. Genet., 77:108.PubMedCrossRefGoogle Scholar
  18. Mattevi, M.S., and Salzano, F.M., 1975, Senescence and human chromosome changes, Humangenetik, 27:1.PubMedGoogle Scholar
  19. Nielsen, J., Jensen, L., Lindhardt, H., Stottrup, L., and Sondergaard, A., 1968, Chromosomes in senile dementia, Br. J. Phsychol., 114:303.CrossRefGoogle Scholar
  20. Saadallah, N., 1984, “Cytogenetic aspects of human male meiosis”, Ph.D. Thesis, The University of Birmingham.Google Scholar
  21. Solari, A.J., 1980, Synaptonemal complexes and associated structures in microspread human spermatocytes, Chromosoma, 81:315.PubMedCrossRefGoogle Scholar
  22. Speed, R.M., 1985, The prophase stages in human foetal oocytes studied by light and electron microscopy, Hum. Genet. 69:69.PubMedCrossRefGoogle Scholar
  23. Stewart, G.D., Hassold, T.J., Berg, A., Watkins, P., Tanzi, R., and Kurnit, D.M., 1988, Trisomy 21 (Down syndrome)): Studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21, Am. J. Human Genet., 42:227.Google Scholar
  24. Sung, W.K., Komatsu, M., and Jagiello, G. (1983), A method for obtaining synaptonemal complexes of human pachytene oocytes, Caryologia 36:315.Google Scholar
  25. Wallace, B.M.N, and Hulten, M.A., 1985, Meiotic chromosome pairing in the human female, Ann. Hum. Genet., 49:215.PubMedCrossRefGoogle Scholar
  26. Warren, A.C., Chakravarti, A., Wong, C., Slaugenhaupt, S.A., Halloran, S.L., Watkins, P.C., Metaxotou, C., and Antonarakis, S.E., 1987, Evidence for reduced recombination on the nondisjoined chromosomes 21 in Down syndrome, Science, 237:652.PubMedCrossRefGoogle Scholar
  27. Wramsby, H., Fredga, K., and Liedholm, P., 1987, Chromosome analysis of human oocytes recovered from preovulatory follicles in stimulated cycles, New Eng. J. Med., 316:121.PubMedCrossRefGoogle Scholar
  28. Zenzes, M.T., de Geyter, C., Bordt, J., Schneider, H.P.G., and Nieschlag, E., 1987, Cytological investigations of human eggs with unsuccessful fertilization, Am. J. Hum. Genet., 41:858.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Judith H. Ford
    • 1
  1. 1.Genetics DepartmentThe Queen Elizabeth HospitalWoodvilleAustralia

Personalised recommendations